Ondrus P, Gregová H, Gábor D, Laca L
Vasa. 1989;18(4):269-72.
The study deals with assessment of the extent of tissue ischaemia and disorders of aerobic metabolism on the basis of comparison of resting arterial, venous values, and the arteriovenous differences in pH, pCO2, pO2, lactate, pyruvate and glucose levels and the lactate/pyruvate index in 32 extremities of 16 healthy individuals and in 42 extremities of 38 patients with chronic ischaemic syndrome of the lower extremity in stages IIb, III and IV according to Fontaine. The group of patients showed significantly higher values of lactate, pyruvate, glucose and the lactate/pyruvate index and lower pH levels than controls. Changes in pCO2, pO2 and pyruvate levels were not significant. Multivariate analysis of data revealed serious impairment of the metabolism of extremities affected by chronic ischaemia.
该研究基于对16名健康个体的32个肢体以及38名根据Fontaine分级处于IIb、III和IV期的下肢慢性缺血综合征患者的42个肢体的静息动脉、静脉值以及pH、pCO2、pO2、乳酸、丙酮酸和葡萄糖水平的动静脉差异和乳酸/丙酮酸指数进行比较，来评估组织缺血程度和有氧代谢紊乱情况。患者组的乳酸、丙酮酸、葡萄糖和乳酸/丙酮酸指数值显著高于对照组，而pH值则低于对照组。pCO2、pO2和丙酮酸水平的变化不显著。数据的多变量分析显示，受慢性缺血影响的肢体代谢严重受损。
