利用磷酸二酯酶抑制剂获取热量限制的益处：来自白藜芦醇的启示。
Using PDE inhibitors to harness the benefits of calorie restriction: lessons from resveratrol.
作者信息
Chung Jay H
机构信息
Laboratory of Obesity and Aging Research, Genetics andDevelopmental Biology Center, National Heart Lung and BloodInstitute, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Aging (Albany NY). 2012 Mar;4(3):144-5. doi: 10.18632/aging.100442.
Abstract
In conclusion, the discovery of the resveratrol-PDE link suggests that PDE4 inhibitors, possibly in combination with other PDE inhibitors, may be useful for mimicking CR and for treating aging-related diseases.
摘要
总之，白藜芦醇与磷酸二酯酶联系的发现表明，磷酸二酯酶4抑制剂，可能与其他磷酸二酯酶抑制剂联合使用，或许对模拟热量限制及治疗衰老相关疾病有用。
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1
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2
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Mol Cell. 2011 Dec 23;44(6):851-63. doi: 10.1016/j.molcel.2011.12.005.
3
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4
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Mech Ageing Dev. 2010 Nov-Dec;131(11-12):739-42. doi: 10.1016/j.mad.2010.09.007. Epub 2010 Oct 8.
5
SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator.小分子激活 SIRT1：酶与激活剂直接相互作用的动力学和生物物理证据。
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6
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