John S McIlhenny Skeletal Muscle Physiology Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, United States.
Exp Gerontol. 2013 Oct;48(10):1018-24. doi: 10.1016/j.exger.2013.04.005. Epub 2013 Apr 25.
Calorie restriction extends lifespan and confers metabolic benefits similar to the effect of lifestyle interventions. Poor compliance to long-term dietary restriction, however, hinders the success of this approach. Evidence is now persuasive for a role of resveratrol supplementation (a polyphenol in red grapes) as potential alternative to calorie restriction. This review summarizes the latest literature on the effects and the molecular mechanisms by which calorie restriction and resveratrol confer health benefits. Resveratrol activates SIRT1 and the associated improvement in energy utilization and insulin sensitivity closely resembles the benefits of calorie restriction. Current data largely support resveratrol as a potential calorie restriction mimetic to improve metabolic and probably functional health. Future studies which characterize the bioavailability and efficacy of resveratrol supplementation are critical to provide evidence for its long-term health benefits.
热量限制可以延长寿命并带来类似于生活方式干预的代谢益处。然而，长期饮食限制的依从性差会阻碍这种方法的成功。现在有证据表明，白藜芦醇补充剂（红葡萄中的一种多酚）作为热量限制的潜在替代方法具有潜力。这篇综述总结了关于热量限制和白藜芦醇带来健康益处的最新文献，包括其作用和分子机制。白藜芦醇激活 SIRT1，改善能量利用和胰岛素敏感性，这与热量限制的益处非常相似。目前的数据在很大程度上支持白藜芦醇作为一种潜在的热量限制模拟物，以改善代谢和可能的功能健康。未来研究需要确定白藜芦醇补充剂的生物利用度和功效，为其长期健康益处提供证据。
