杏仁核中 μ-阿片受体的可用性与吸烟缓解负性情绪有关。
μ-Opioid receptor availability in the amygdala is associated with smoking for negative affect relief.
机构信息
Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Psychopharmacology (Berl). 2012 Aug;222(4):701-8. doi: 10.1007/s00213-012-2673-5. Epub 2012 Mar 3.
RATIONALE
The perception that smoking relieves negative affect contributes to smoking persistence. Endogenous opioid neurotransmission, and the μ-opioid receptor (MOR) in particular, plays a role in affective regulation and is modulated by nicotine.
OBJECTIVES
We examined the relationship of MOR binding availability in the amygdala to the motivation to smoke for negative affect relief and to the acute effects of smoking on affective responses.
METHODS
Twenty-two smokers were scanned on two separate occasions after overnight abstinence using [¹¹C]carfentanil positron emission tomography imaging: after smoking a nicotine-containing cigarette and after smoking a denicotinized cigarette. Self-reports of smoking motives were collected at baseline, and measures of positive and negative affect were collected pre- and post- cigarette smoking.
RESULTS
Higher MOR availability in the amygdala was associated with motivation to smoke to relieve negative affect. However, MOR availability was unrelated to changes in affect after smoking either cigarette.
CONCLUSIONS
Increased MOR availability in amygdala may underlie the motivation to smoke for negative affective relief. These results are consistent with previous data highlighting the role of MOR neurotransmission in smoking behavior.
原理
吸烟缓解负面情绪的认知有助于吸烟持续存在。内源性阿片神经递质传递，特别是 μ 阿片受体（MOR），在情感调节中发挥作用，并受尼古丁调节。
目的
我们研究了杏仁核中 MOR 结合可用性与吸烟缓解负面情绪的动机之间的关系，以及吸烟对情感反应的急性影响。
方法
22 名吸烟者在两次单独的情况下进行了研究，两次均在一夜的禁欲后进行：一次是在吸含尼古丁的香烟后，一次是在吸去尼古丁的香烟后。在基线时收集吸烟动机的自我报告，在吸烟前和吸烟后收集积极和消极情绪的测量值。
结果
杏仁核中 MOR 可用性越高，吸烟缓解负面情绪的动机就越强。然而，MOR 可用性与吸烟后情绪的变化无关。
结论
杏仁核中 MOR 可用性的增加可能是吸烟缓解负面情绪的动机。这些结果与先前强调 MOR 神经传递在吸烟行为中的作用的数据一致。
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