杏仁核的结构和功能连接：从正常情绪到病理性焦虑。
The structural and functional connectivity of the amygdala: from normal emotion to pathological anxiety.
机构信息
Department of Psychological & Brain Sciences, Dartmouth College, 6207 Moore Hall, Hanover, NH 03755, USA.
出版信息
Behav Brain Res. 2011 Oct 1;223(2):403-10. doi: 10.1016/j.bbr.2011.04.025. Epub 2011 Apr 22.
Abstract
The dynamic interactions between the amygdala and the medial prefrontal cortex (mPFC) are usefully conceptualized as a circuit that both allows us to react automatically to biologically relevant predictive stimuli as well as regulate these reactions when the situation calls for it. In this review, we will begin by discussing the role of this amygdala-mPFC circuitry in the conditioning and extinction of aversive learning in animals. We will then relate these data to emotional regulation paradigms in humans. Finally, we will consider how these processes are compromised in normal and pathological anxiety. We conclude that the capacity for efficient crosstalk between the amygdala and the mPFC, which is represented as the strength of the amygdala-mPFC circuitry, is crucial to beneficial outcomes in terms of reported anxiety.
摘要
杏仁核和内侧前额叶皮质（mPFC）之间的动态相互作用可以很好地被概念化为一个回路，这个回路使我们能够对生物相关的预测性刺激自动做出反应，并且在情况需要时对这些反应进行调节。在这篇综述中，我们将首先讨论这个杏仁核-mPFC 回路在动物的厌恶学习的条件作用和消退中的作用。然后，我们将把这些数据与人类的情绪调节范式联系起来。最后，我们将考虑这些过程在正常和病理性焦虑中的受损情况。我们的结论是，杏仁核和 mPFC 之间有效串扰的能力，表现为杏仁核-mPFC 回路的强度，对于报告的焦虑的有益结果是至关重要的。
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