主题综述系列：2012 年生物学中的金属
Thematic minireview series: Metals in Biology 2012.
机构信息
Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, USA.
出版信息
J Biol Chem. 2012 Apr 20;287(17):13508-9. doi: 10.1074/jbc.R112.355933. Epub 2012 Mar 2.
Abstract
Metals are present in about one-half of the protein structures available and also have critical roles in nucleic acid biochemistry. This prologue introduces the fourth of the Thematic Minireview Series on Metals in Biology, which deals with several topics involving iron, manganese, copper, and other metals. The six minireviews discuss metal transport and intracellular homeostasis, including chaperones and siderophores, maturation of the diiron active sites in hydrogenases, the balance between manganese and iron, and copper homeostasis relevant to pathogens.
摘要
金属存在于大约一半的可用蛋白质结构中，在核酸生物化学中也具有关键作用。这篇序言介绍了生物学中关于金属的第四个专题综述系列，涉及几个涉及铁、锰、铜和其他金属的主题。这六篇综述讨论了金属运输和细胞内稳态，包括伴侣蛋白和铁载体，氢化酶中二铁活性中心的成熟，锰和铁之间的平衡，以及与病原体相关的铜稳态。
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