引言：生物学中的金属：宿主 - 病原体界面处的金属
Introduction: Metals in Biology: METALS AT THE HOST-PATHOGEN INTERFACE.
作者信息
Guengerich F Peter
机构信息
From the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146
出版信息
J Biol Chem. 2015 Jul 31;290(31):18943-4. doi: 10.1074/jbc.R115.670265. Epub 2015 Jun 8.
Abstract
This seventh Metals in Biology Thematic Series deals with the metal-based interactions of mammalian hosts with pathogens. Both pathogens and hosts have complex regulatory systems for metal homeostasis. Understanding these provides strategies for fighting pathogens, either by excluding essential metals from the microbes, by delivery of excess metals to cause toxicity, or by complexing metals in microorganisms. Intervention is possible by delivery of complexing reagents or by targeting the microbial regulatory apparatus.
摘要
本期《生物学中的金属》主题系列的第七期探讨了哺乳动物宿主与病原体之间基于金属的相互作用。病原体和宿主都拥有复杂的金属稳态调节系统。了解这些系统可为对抗病原体提供策略，方法包括从微生物中排除必需金属、输送过量金属以产生毒性，或使微生物中的金属络合。通过递送络合试剂或靶向微生物调节机制都有可能实现干预。
相似文献
1
Introduction: Metals in Biology: METALS AT THE HOST-PATHOGEN INTERFACE.
J Biol Chem. 2015 Jul 31;290(31):18943-4. doi: 10.1074/jbc.R115.670265. Epub 2015 Jun 8.
2
Copper at the Fungal Pathogen-Host Axis.
J Biol Chem. 2015 Jul 31;290(31):18945-53. doi: 10.1074/jbc.R115.649129. Epub 2015 Jun 8.
3
Metal limitation and toxicity at the interface between host and pathogen.
FEMS Microbiol Rev. 2014 Nov;38(6):1235-49. doi: 10.1111/1574-6976.12087. Epub 2014 Sep 29.
4
Role of divalent metals in infectious disease susceptibility and outcome.
Clin Microbiol Infect. 2018 Jan;24(1):16-23. doi: 10.1016/j.cmi.2017.01.018. Epub 2017 Jan 29.
5
Transition Metals and Virulence in Bacteria.
Annu Rev Genet. 2016 Nov 23;50:67-91. doi: 10.1146/annurev-genet-120215-035146. Epub 2016 Sep 7.
6
Transition metals at the host-pathogen interface: how exploit human metalloproteins for acquiring iron and zinc.
Essays Biochem. 2017 May 9;61(2):211-223. doi: 10.1042/EBC20160084.
7
Molecular Evolution of Transition Metal Bioavailability at the Host-Pathogen Interface.
Trends Microbiol. 2021 May;29(5):441-457. doi: 10.1016/j.tim.2020.08.001. Epub 2020 Sep 18.
8
Nutritional immunity: the battle for nutrient metals at the host-pathogen interface.
Nat Rev Microbiol. 2022 Nov;20(11):657-670. doi: 10.1038/s41579-022-00745-6. Epub 2022 May 31.
9
Essential metals at the host-pathogen interface: nutritional immunity and micronutrient assimilation by human fungal pathogens.
FEMS Yeast Res. 2015 Nov;15(7). doi: 10.1093/femsyr/fov071. Epub 2015 Aug 4.
10
The Role of Intermetal Competition and Mis-Metalation in Metal Toxicity.
Adv Microb Physiol. 2017;70:315-379. doi: 10.1016/bs.ampbs.2017.01.003. Epub 2017 Feb 13.
引用本文的文献
1
Introduction to Metals in Biology 2018: Copper homeostasis and utilization in redox enzymes.
J Biol Chem. 2018 Mar 30;293(13):4603-4605. doi: 10.1074/jbc.TM118.002255. Epub 2018 Feb 7.
2
Introduction to Metals in Biology 2017: Iron transport, storage, and the ramifications.
J Biol Chem. 2017 Aug 4;292(31):12725-12726. doi: 10.1074/jbc.R117.801332. Epub 2017 Jun 14.
3
Metals in Biology 2016: Molecular Basis of Selection of Metals by Enzymes.
J Biol Chem. 2016 Sep 30;291(40):20838-20839. doi: 10.1074/jbc.R116.749259. Epub 2016 Jul 26.
4
Introduction: Metals in Biology: α-Ketoglutarate/Iron-Dependent Dioxygenases.
J Biol Chem. 2015 Aug 21;290(34):20700-20701. doi: 10.1074/jbc.R115.675652. Epub 2015 Jul 7.
本文引用的文献
1
Copper at the Fungal Pathogen-Host Axis.
J Biol Chem. 2015 Jul 31;290(31):18945-53. doi: 10.1074/jbc.R115.649129. Epub 2015 Jun 8.
2
Regulation of Iron Metabolism by Hepcidin under Conditions of Inflammation.
J Biol Chem. 2015 Jul 31;290(31):18975-83. doi: 10.1074/jbc.R115.650150. Epub 2015 Jun 8.
3
Nramp1 and Other Transporters Involved in Metal Withholding during Infection.
J Biol Chem. 2015 Jul 31;290(31):18984-90. doi: 10.1074/jbc.R115.643973. Epub 2015 Jun 8.
4
Microbial Copper-binding Siderophores at the Host-Pathogen Interface.
J Biol Chem. 2015 Jul 31;290(31):18967-74. doi: 10.1074/jbc.R115.644328. Epub 2015 Jun 8.
5
Nutritional Immunity: S100 Proteins at the Host-Pathogen Interface.
J Biol Chem. 2015 Jul 31;290(31):18991-8. doi: 10.1074/jbc.R115.645085. Epub 2015 Jun 8.
6
Mycobacterium tuberculosis and Copper: A Newly Appreciated Defense against an Old Foe?
J Biol Chem. 2015 Jul 31;290(31):18962-6. doi: 10.1074/jbc.R115.640193. Epub 2015 Jun 8.
7
The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens.
J Biol Chem. 2015 Jul 31;290(31):18954-61. doi: 10.1074/jbc.R115.647099. Epub 2015 Jun 8.
8
CO-releasing Metal Carbonyl Compounds as Antimicrobial Agents in the Post-antibiotic Era.
J Biol Chem. 2015 Jul 31;290(31):18999-9007. doi: 10.1074/jbc.R115.642926. Epub 2015 Jun 8.
9
Thematic minireview series: metals in biology 2014.
J Biol Chem. 2014 Oct 10;289(41):28094. doi: 10.1074/jbc.R114.607093. Epub 2014 Aug 26.
10
Thematic minireview series: metals in biology 2013.
J Biol Chem. 2013 May 10;288(19):13164. doi: 10.1074/jbc.R113.467712. Epub 2013 Mar 28.
Zotero 插件