Dehghani Seyed Mohsen, Imanieh Mohammad Hadi, Oboodi Roya, Haghighat Mahmood
Gastroenterohepatology Research Center, Pediatric Gastroenterology Department, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz 71937-11351, Iran.
ISRN Pediatr. 2011;2011:219287. doi: 10.5402/2011/219287. Epub 2011 Apr 5.
Background. Functional dyspepsia is a common chronic disorder with non specific upper abdominal pain or discomfort. Different approaches with anti-secretory, spasmolytic, prokinetic and anti-inflammatory effects and most preferably reduction of visceral hypersensitivity seem logical. In this study, we compared the effectiveness of the four most drugs used for treatment of dyspepsia in children. Methods. 169 patients between 2 to 16 years old that 47.3% was male and 52.7% was female were enrolled in this clinical trial study by the diagnosis of functional dyspepsia. Then for each patient one of the drugs; Omeprazole, Famotidine, Ranitidine or Cimetidine was administered, for a period of 4 weeks. Patients were followed after 2 and 6 weeks from the beginning of the treatment. Results. The distribution of drugs between these patients were including; 21.9% with Cimetidine, 21.3% with Famotidine, 30.8% with Omeperazole and 26% with Ranitidine that the proportion of patients with all symptoms relief were: 21.6% for Cimetidine, 44.4% for Famotidine, 53.8% for Omeprazole and 43.2% for Cimetidine (P = .024). In followups within 2 and 6 weeks after beginning medical therapy, no side effects due to drugs were seen. Conclusion. If a cure is defined as all symptoms relief after a period of 4 weeks treatment, our findings showed that Omeperazole are superior to Ranitidine, Famotidine, and Cimetidine for management of functional dyspepsia.
背景。功能性消化不良是一种常见的慢性疾病，表现为非特异性上腹部疼痛或不适。采用具有抗分泌、解痉、促动力和抗炎作用，最理想的是降低内脏高敏感性的不同方法似乎是合理的。在本研究中，我们比较了用于治疗儿童消化不良的四种最常用药物的疗效。方法。169名年龄在2至16岁之间的患者纳入了这项临床试验研究，其中47.3%为男性，52.7%为女性，经诊断为功能性消化不良。然后给每位患者使用一种药物；奥美拉唑、法莫替丁、雷尼替丁或西咪替丁，为期4周。从治疗开始后2周和6周对患者进行随访。结果。这些患者中药物的分布情况如下；21.9%使用西咪替丁，21.3%使用法莫替丁，30.8%使用奥美拉唑，26%使用雷尼替丁，所有症状缓解的患者比例分别为：西咪替丁为21.6%，法莫替丁为44.4%，奥美拉唑为53.8%，西咪替丁为43.2%（P = 0.024）。在开始药物治疗后的2周和6周随访中，未发现药物引起的副作用。结论。如果将治愈定义为经过4周治疗后所有症状缓解，我们的研究结果表明，奥美拉唑在治疗功能性消化不良方面优于雷尼替丁、法莫替丁和西咪替丁。
