School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India.
Biochem J. 2012 May 1;443(3):619-25. doi: 10.1042/BJ20120143.
A novel co-regulation exists between the first step of GPI (glycosylphosphatidylinositol) anchor biosynthesis and the rate-determining step of ergosterol biosynthesis in Candida albicans. Depleting CaGpi19p, an accessory subunit of the enzyme complex that initiates GPI biosynthesis, down-regulates ERG11, altering ergosterol levels and drug response. This effect is specific to CaGpi19p depletion and is not due to cell wall defects or GPI deficiency. Additionally, down-regulation of ERG11 down-regulates CaGPI19 and GPI biosynthesis.
在白色念珠菌中，GPI（糖基磷脂酰肌醇）锚生物合成的第一步和麦角固醇生物合成的限速步骤之间存在一种新的共调控关系。耗尽参与 GPI 生物合成的酶复合物的辅助亚基 CaGpi19p，会下调 ERG11，改变麦角固醇水平和药物反应。这种效应是 CaGpi19p 耗竭所特有的，不是由于细胞壁缺陷或 GPI 缺乏所致。此外，下调 ERG11 会下调 CaGPI19 和 GPI 的生物合成。
