Department of Respiratory Diseases, University Ghent, Belgium.
Curr Pharm Des. 2012;18(16):2305-13. doi: 10.2174/138161212800166004.
Vaccinations have been given to people for at least 100 years of which 80 years formulated in adjuvants. Currently, aluminium- containing formulas and the oil-based substance called MF59 are the two adjuvants licensed for clinical use. Despite the massive use of aluminium adjuvant, its mechanism of action has been only recently addressed. In this review, we will discuss both the cellular and molecular mode of action of aluminium-containing adjuvants.
疫苗接种已经进行了至少 100 年，其中 80 年是在佐剂的帮助下进行的。目前，含铝配方和称为 MF59 的油性物质是两种获准用于临床的佐剂。尽管大量使用铝佐剂，但直到最近才研究其作用机制。在这篇综述中，我们将讨论含铝佐剂的细胞和分子作用模式。
