Ghizzoni L, Lamborghini A, Ziveri M, Volta C, Panza C, Balestrazzi P, Bernasconi S
Department of Pediatrics, University of Parma, Italy.
Acta Endocrinol (Copenh). 1990 Sep;123(3):291-7. doi: 10.1530/acta.0.1230291.
To determine whether the quantitative and qualitative aspects of GH secretion in girls with Turner's syndrome are similar to those of short-normal children we studied the 24-h GH secretion of 10 patients with Turner's syndrome and 9 short-normal children with comparable auxological features. GH profiles, obtained by 30-min sampling, were analysed by the Pulsar programme. The pulsatile GH release over the 24 h in Turner's syndrome was similar to that in normal children. However, when the GH release over the 12 day and night hours were separately analysed, only normal children showed a night-time increase in the sum of peak amplitudes. Moreover, patients with Turner's syndrome had significantly decreased number and frequency of peaks in the night-time compared with short children. In short-normal children but not in Turner's syndrome, height velocity was related to the 24-h integrated concentration of GH, area under the curve over zero-line and over baseline, sum of peak areas, and amplitudes. Night-time GH area over zero-line and over baseline, mean peak amplitude, height area, sum of peak area and amplitudes were positively correlated with height velocity in short children, whereas in Turner's syndrome height velocity was related to daytime parameters only. In conclusion, girls with Turner's syndrome have a discrete pattern of pulsatile GH release. However, the relation of GH secretion to growth in these patients, is uncertain.
为了确定特纳综合征女孩生长激素（GH）分泌的定量和定性方面是否与身材正常矮小儿童相似，我们研究了10例特纳综合征患者和9例具有可比生长学特征的身材正常矮小儿童的24小时GH分泌情况。通过30分钟采样获得的GH谱，采用Pulsar程序进行分析。特纳综合征患者24小时内的脉冲式GH释放与正常儿童相似。然而，当分别分析白天和夜间12小时的GH释放时，只有正常儿童夜间的峰值幅度总和出现增加。此外，与身材矮小儿童相比，特纳综合征患者夜间的峰值数量和频率显著降低。在身材正常矮小儿童中，身高增长速度与24小时GH综合浓度、零线上和基线以上的曲线下面积、峰值面积总和及幅度相关，而在特纳综合征患者中，身高增长速度仅与白天参数相关。身材矮小儿童夜间零线上和基线以上的GH面积、平均峰值幅度、身高面积、峰值面积总和及幅度与身高增长速度呈正相关，而在特纳综合征患者中，身高增长速度仅与白天参数相关。总之，特纳综合征女孩具有离散的脉冲式GH释放模式。然而，这些患者中GH分泌与生长的关系尚不确定。
