阿利吉仑、氨氯地平和氢氯噻嗪三联组合治疗高血压。
Aliskiren, amlodipine and hydrochlorothiazide triple combination for hypertension.
作者信息
Judd Eric, Jaimes Edgar A
机构信息
University of Alabama at Birmingham, Vascular Biology and Hypertension Program, 115 Community Health Services Building, 933 19th Street South, Birmingham, AL, USA.
出版信息
Expert Rev Cardiovasc Ther. 2012 Mar;10(3):293-303. doi: 10.1586/erc.12.7.
Abstract
Cardiovascular-related morbidity and mortality is linked to hypertension with proportional gains in cardiovascular risk factor reduction with the lowering of blood pressure. Clinical trial data has shown that attaining goal blood pressure requires, for most patients, at least two antihypertensive medications, with a significant proportion requiring regimens of three or more medications. Single-pill triple combinations have returned to the market following results of increased efficacy and adherence over dual- and mono-therapy. The combination of aliskiren, amlodipine and hydrochlorothiazide is a rational choice for combination therapy and recent studies suggest that it is safe and effective in lowering blood pressure in patients who fail dual combination therapy.
摘要
心血管相关的发病率和死亡率与高血压相关，随着血压降低，心血管危险因素的降低成比例增加。临床试验数据表明，对于大多数患者而言，要达到目标血压至少需要两种抗高血压药物，相当一部分患者需要三种或更多药物的治疗方案。单 pill 三联组合在疗效和依从性方面优于双联和单药治疗后已重新上市。阿利吉仑、氨氯地平和氢氯噻嗪的组合是联合治疗的合理选择，最近的研究表明，它在双联联合治疗失败的患者中降低血压是安全有效的。
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引用本文的文献
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Integr Blood Press Control. 2013 Jun 14;6:59-67. doi: 10.2147/IBPC.S32649. Print 2013.
本文引用的文献
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J Clin Hypertens (Greenwich). 2011 Aug;13(8):571-81. doi: 10.1111/j.1751-7176.2011.00483.x. Epub 2011 Jun 20.
2
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