患有甲状腺自身抗体的健康孕妇的甲状腺大小和功能。与产后甲状腺炎发生的关系。

Thyroid size and function in healthy pregnant women with thyroid autoantibodies. Relation to development of postpartum thyroiditis.

作者信息

Rasmussen N G, Hornnes P J, Høier-Madsen M, Feldt-Rasmussen U, Hegedüs L

机构信息

Department of Obstetrics and Gynecology, Gentofte Hospital, University of Copenhagen, Denmark.

出版信息

Acta Endocrinol (Copenh). 1990 Oct;123(4):395-401. doi: 10.1530/acta.0.1230395.

DOI:10.1530/acta.0.1230395

PMID:2239087

Abstract

In a study of postpartum thyroiditis, thyroid function and ultrasonically determined thyroid size were evaluated in 36 thyroid autoantibody positive healthy women during pregnancy and the first postpartum year. Twelve women (33%) developed postpartum thyroiditis with permanent thyroid dysfunction in three. However, only one woman had symptoms and needed treatment. The most common type of thyroid dysfunction was a transient hyperthyroid phase as seen in 7 women. A significant increase by 20-30% in mean thyroid volume during pregnancy was demonstrated independent of development of postpartum thyroiditis. We conclude that initial thyroid volume or changes during pregnancy and post partum are not useful indicators of the development of postpartum thyroiditis. The fact that the condition is oligosymptomatic suggests that screening procedures are necessary if one wants to diagnose the earliest phases of postpartum thyroiditis.

摘要

在一项关于产后甲状腺炎的研究中，对36名甲状腺自身抗体阳性的健康女性在孕期及产后第一年的甲状腺功能和超声测定的甲状腺大小进行了评估。12名女性（33%）发生了产后甲状腺炎，其中3人出现永久性甲状腺功能障碍。然而，只有1名女性有症状并需要治疗。最常见的甲状腺功能障碍类型是短暂的甲亢期，7名女性出现此情况。孕期甲状腺平均体积显著增加20% - 30%，且与产后甲状腺炎的发生无关。我们得出结论，孕期及产后初期的甲状腺体积或变化并非产后甲状腺炎发生的有用指标。该病症状较少这一事实表明，如果想要诊断产后甲状腺炎的早期阶段，筛查程序是必要的。