Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109-5632, USA.
Schizophr Bull. 2012 Sep;38(5):914-9. doi: 10.1093/schbul/sbs011. Epub 2012 Mar 5.
The history of the chemical synthesis and animal/human pharmacology of phencyclidine is documented. From its early use as a general anesthetic, chemical model of schizophrenia, and drug of abuse, phencyclidine has had a checkered history. Research with this agent and its chemical derivatives like ketamine have provided a solid foundation for just a beginning to understanding the neuropathology of schizophrenia.
本文记录了苯环己哌啶的化学合成和动物/人体药理学的历史。从它早期作为全身麻醉剂、精神分裂症的化学模型和滥用药物的使用，苯环己哌啶的历史充满了曲折。对该药物及其化学衍生物如氯胺酮的研究为理解精神分裂症的神经病理学提供了坚实的基础。
