Wong D M, Ghosh A, Fales-Williams A J, Haynes J S, Kanthasamy A G
Department of Veterinary Clinical Sciences, Lloyd Veterinary Medical Center, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.
Vet Pathol. 2012 Nov;49(6):1049-53. doi: 10.1177/0300985812439074. Epub 2012 Mar 5.
The cervical spinal cords of 2 horses with equine degenerative myeloencephalopathy (EDM) were evaluated for evidence of oxidative damage to the central nervous system (CNS) using immunohistochemical staining for 3-nitrotyrosine (3-NT) and 4-hydroxynonenol (4-HNE). Neurons of the CNS from horses with EDM had positive immunohistochemical staining, whereas control samples did not, thus supporting the theory that oxidative damage is a potential underlying factor in horses with EDM. In addition, serum vitamin E concentration was low in both EDM-affected horses, and vitamin E concentration was also deficient in the cerebrospinal fluid in 1 EDM horse, further supporting the association between low vitamin E concentrations and oxidative damage to the CNS. Continued research is necessary to further define the pathophysiologic mechanisms of EDM.
对2匹患有马退行性脊髓脑病（EDM）的马的颈脊髓进行评估，使用3-硝基酪氨酸（3-NT）和4-羟基壬烯醛（4-HNE）的免疫组织化学染色来检测中枢神经系统（CNS）氧化损伤的证据。患有EDM的马的中枢神经系统神经元免疫组织化学染色呈阳性，而对照样本则没有，从而支持了氧化损伤是EDM马潜在潜在因素的理论。此外，两匹受EDM影响的马的血清维生素E浓度均较低，且一匹EDM马的脑脊液中维生素E浓度也不足，这进一步支持了低维生素E浓度与中枢神经系统氧化损伤之间的关联。有必要继续进行研究以进一步明确EDM的病理生理机制。
