Simultaneous genetic analysis of longitudinal means and covariance structure using the simplex model: application to repeatedly measured weight in a sample of 164 female twins.

The simultaneous analysis of means and covariance structures is applied to longitudinal twin data. Body weight was measured on six occasions in a sample of young female MZ and DZ twins. When average body weight at the first measurement occasion, as well as the increments in weight at later occasions, are specified in the genetic part of the model that also adequately explains the covariance structure, a good fit is obtained. In this application the increase in body weight at each occasion is weighted by the square root of the genetic variance innovation terms that represent the new genetic variance entering into the process.