利用双胞胎数据对单形模型中的纵向均值和协方差结构进行同步遗传分析。

Simultaneous genetic analysis of longitudinal means and covariance structure in the simplex model using twin data.

作者信息

Dolan C V, Molenaar P C, Boomsma D I

机构信息

Department of Psychology, University of Amsterdam, The Netherlands.

出版信息

Behav Genet. 1991 Jan;21(1):49-65. doi: 10.1007/BF01067666.

DOI:10.1007/BF01067666

PMID:2018463

Abstract

A longitudinal model based on the simplex model is presented to analyze simultaneously means and covariance structure using univariate longitudinal twin data. The objective of the model is to decompose the mean trend into components which can be attributed to those genetic and environmental factors which give rise to phenotypic individual differences and a component of unknown constitution which does not involve individual differences. Illustrations are given using simulated data and repeatedly measured weight obtained in a sample of 82 female twin pairs on six occasions.

摘要

提出了一种基于单形模型的纵向模型，用于使用单变量纵向双胞胎数据同时分析均值和协方差结构。该模型的目的是将均值趋势分解为可归因于那些导致表型个体差异的遗传和环境因素的成分，以及一个不涉及个体差异的未知构成成分。使用模拟数据和在82对女性双胞胎样本中六次重复测量的体重给出了示例。