Raatikainen T, Väänänen K, Tamelander G
Oulu University, Department of Surgery, Finland.
Acta Orthop Scand. 1990 Oct;61(5):443-8. doi: 10.3109/17453679008993559.
The effect of glycosaminoglycan polysulfate (GAGPS) on damaged patellar cartilage and clinical symptoms of chondromalacia was studied on 31 patients in a placebo-controlled double-blind trial. The clinical diagnosis was confirmed by arthroscopy. The treatment consisted of 12 intramuscular injections of either GAGPS or placebo, and the patients were followed for 1 year. In 26 patients, rearthroscopy was performed at the 1-year follow-up. Comparison of the two arthroscopies showed improvement in 8/13 patients in the GAGPS group compared with 3/13 in the placebo group. The clinical parameters correlated well with the results of the arthroscopies. The results support the use of GAGPS for chondromalacia patellae.
在一项安慰剂对照双盲试验中，对31例患者研究了硫酸糖胺聚糖（GAGPS）对受损髌软骨及髌骨软化症临床症状的影响。临床诊断经关节镜检查确认。治疗包括给患者肌肉注射12次GAGPS或安慰剂，随后对患者随访1年。26例患者在1年随访时接受了再次关节镜检查。两次关节镜检查结果对比显示，GAGPS组13例患者中有8例病情改善，而安慰剂组13例中仅有3例改善。临床参数与关节镜检查结果高度相关。这些结果支持将GAGPS用于治疗髌骨软化症。
