Warren L, Buck C A, Tuszynski G P
Dev Biol Stand. 1979;42:177-82.
Comparisons have been made of the carbohydrates bound to membrane proteins of control and malignant cells in culture. It has been found that most individual glycoproteins of control and malignant cells differ in their carbohydrate components. Differences between control and malignant cells have been foundin the glycoproteins of the various membrane systems (surface, nucleus, mitochondria, endoplasmic reticulum). It is suggested that the extensive changes in bound carbohydrates of the malignant cell permit the cell to live and divide but isolate the cell functionally. The extensive structural changes may also be responsible for the cascading of involvement of various processes within the malignant cell.
已对培养中的对照细胞和恶性细胞的膜蛋白结合碳水化合物进行了比较。发现对照细胞和恶性细胞的大多数单个糖蛋白在碳水化合物成分上存在差异。在各种膜系统（表面、细胞核、线粒体、内质网）的糖蛋白中发现了对照细胞和恶性细胞之间的差异。有人提出，恶性细胞膜结合碳水化合物的广泛变化使细胞能够存活和分裂，但在功能上使细胞孤立。广泛的结构变化也可能是恶性细胞内各种过程连锁反应的原因。
