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自发性小脑出血的长期预后和预后因素。

Long-term outcome and prognostic factors after spontaneous cerebellar hemorrhage.

机构信息

Cardiology Division, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China.

出版信息

Cerebellum. 2012 Dec;11(4):939-45. doi: 10.1007/s12311-012-0371-9.

Abstract

Cerebellar hemorrhage is the least common type of intracranial hemorrhage (ICH) encountered in clinical practice, and clinical data concerning the long-term outcomes are limited. This study aimed to investigate the long-term outcomes following spontaneous cerebellar hemorrhage in a cohort of Chinese patients. This single-center observational study was carried out between 1996 and 2010 and included 72 consecutive Chinese patients with a first spontaneous cerebellar hemorrhage. Of 440 patients with primary ICH, 72 (16.4%) had primary cerebellar hemorrhage. The mean age was 67.5 ± 12.3 years and patients were predominantly male (54%). The 30-day mortality was 16.7% with Glasgow coma scale ≤ 8 as the only predictor. At 6 months, 56.7% of patients who survived the first 30 days had a persistently poor functional status with modified Rankin scale score >2. After a mean follow-up of 4.7 years, 3.3% of patients had recurrent ICH, a recurrence rate of 7.3 per 1,000 patient-years. Ischemic stroke occurred in 12% of patients, an incidence of 25.5 per 1,000 patient-years. This study provided data on the long-term outcome of post-cerebellar hemorrhage in Chinese patients.

摘要

小脑出血是临床实践中最不常见的颅内出血(ICH)类型,关于其长期预后的数据有限。本研究旨在调查中国患者自发性小脑出血后的长期预后。这是一项单中心观察性研究,于 1996 年至 2010 年进行,纳入了 72 例连续的中国自发性小脑出血患者。在 440 例原发性 ICH 患者中,72 例(16.4%)为原发性小脑出血。平均年龄为 67.5±12.3 岁,患者以男性为主(54%)。30 天死亡率为 16.7%,格拉斯哥昏迷量表≤8 是唯一的预测因素。在 30 天存活的患者中,6 个月时 56.7%的患者持续存在功能状态差,改良 Rankin 量表评分>2。平均随访 4.7 年后,3.3%的患者发生复发性 ICH,复发率为每 1000 患者年 7.3 例。12%的患者发生缺血性卒中,发生率为每 1000 患者年 25.5 例。本研究提供了中国患者小脑出血后长期预后的数据。

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