Polberger S K, Fex G, Räihä N C
Department of Paediatrics, University of Lund, Malmö General Hospital, Sweden.
Acta Paediatr Scand. 1990 Aug-Sep;79(8-9):729-36. doi: 10.1111/j.1651-2227.1990.tb11547.x.
Plasma samples obtained at birth from 70 very low birth weight (VLBW) infants (gestational age 24 to 34 weeks) and from 20 term infants were analysed for concentrations of 12 different proteins. The plasma concentrations of albumin, transthyretin (TTR), retinol-binding protein (RBP), vitamin D-binding protein, apolipoprotein A I, fibronectin, orosomucoid and alpha 1-antichymotrypsin were significantly lower in the VLBW infants than in the term infants, whereas the values of alpha-fetoprotein (AFP) were significantly higher in the VLBW infants. No differences were found between the two groups for apolipoprotein A II, apolipoprotein B and transferrin. Birth asphyxia and sex had no influence on the measured plasma protein concentrations. The plasma concentrations of apolipoprotein A I and A II were significantly lower in small-for-gestational age (SGA), VLBW infants compared with appropriate-for-gestational age (AGA), VLBW infants. Possible acute inflammation (defined as raised concentrations of orosomucoid or alpha 1-antichymotrypsin) was associated with significantly higher values of vitamin D-binding protein in both VLBW and term infants, suggesting that this protein may act as an acute phase protein in newborn infants.
对出生时采集的70名极低出生体重（VLBW）婴儿（胎龄24至34周）和20名足月儿的血浆样本进行了12种不同蛋白质浓度的分析。VLBW婴儿血浆中白蛋白、转甲状腺素蛋白（TTR）、视黄醇结合蛋白（RBP）、维生素D结合蛋白、载脂蛋白A I、纤连蛋白、类粘蛋白和α1 -抗糜蛋白酶的浓度显著低于足月儿，而VLBW婴儿甲胎蛋白（AFP）的值显著更高。两组间载脂蛋白A II、载脂蛋白B和转铁蛋白未发现差异。出生窒息和性别对所测血浆蛋白浓度无影响。与适于胎龄（AGA）的VLBW婴儿相比，小于胎龄（SGA）的VLBW婴儿血浆中载脂蛋白A I和A II的浓度显著更低。在VLBW婴儿和足月儿中，可能的急性炎症（定义为类粘蛋白或α1 -抗糜蛋白酶浓度升高）均与维生素D结合蛋白的显著更高值相关，这表明该蛋白可能在新生儿中作为一种急性期蛋白发挥作用。
