Naeraa R W, Eiken M, Legarth E G, Nielsen J
Cytogenetic Laboratory, Aarhus Psychiatric Hospital, Denmark.
Acta Paediatr Scand. 1990 Aug-Sep;79(8-9):776-83. doi: 10.1111/j.1651-2227.1990.tb11554.x.
Various methods are used for prediction of final height in girls with Turner's syndrome (TS), but their accuracy has not been systematically investigated or compared. We have compared predictions of final height made with the most commonly used methods in 20 Turner girls at ages 9.5-18 years. Growth standards based on growth and final height of 78 Danish Turner women were used for calculation of standard deviation scores (SDS). In order to provide the necessary basis for "index of potential height" (IPH) method, bone age development was determined from 74 X-rays of 38 untreated Turner girls aged 5.2-19 years. This method was further modified and improved for use in TS. Prediction methods based only on height and chronological age (CA) showed little difference from methods including bone age. The IPH method in our modification was more accurate than those of Bayley-Pinneau and Tanner. At younger ages the IPH method showed better results when using Tanner-Whitehouse 2 (TW2) bone age than when using Greulich-Pyle bone age. Accuracy of predictions were considerably improved by combining methods with and without allowance for bone age. Combinations including the IPH method based on TW2 bone age appeared to be the most accurate. Predictions of final height in Turner's syndrome should therefore be made by combining the IPH method and one of the methods based on height and CA.
人们使用各种方法来预测特纳综合征（TS）女孩的最终身高，但这些方法的准确性尚未得到系统研究或比较。我们比较了20名年龄在9.5至18岁的特纳综合征女孩使用最常用方法预测的最终身高。基于78名丹麦特纳综合征女性的生长和最终身高的生长标准用于计算标准差分数（SDS）。为了为“潜在身高指数”（IPH）方法提供必要依据，对38名年龄在5.2至19岁未经治疗的特纳综合征女孩的74张X光片进行了骨龄发育测定。该方法在特纳综合征中的应用得到了进一步修改和完善。仅基于身高和实足年龄（CA）的预测方法与包括骨龄的方法相比差异不大。我们改进后的IPH方法比贝利-皮诺和坦纳的方法更准确。在较年轻的年龄段，使用坦纳-怀特豪斯2（TW2）骨龄时，IPH方法的结果比使用格吕利希-派尔骨龄时更好。结合考虑和不考虑骨龄的方法，预测的准确性有了显著提高。包括基于TW2骨龄的IPH方法的组合似乎是最准确的。因此，特纳综合征最终身高的预测应通过结合IPH方法和基于身高及实足年龄的方法之一来进行。
