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The Effect of Neoadjuvant Therapy on Early Complications of Esophageal Cancer Surgery.新辅助治疗对食管癌手术早期并发症的影响。
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本文引用的文献

1
Effects of neoadjuvant therapy on perioperative morbidity in elderly patients undergoing esophagectomy for esophageal cancer.新辅助治疗对老年食管癌患者行食管切除术后围手术期发病率的影响。
Ann Surg Oncol. 2007 Nov;14(11):3243-50. doi: 10.1245/s10434-007-9455-z. Epub 2007 Aug 23.
2
Neoadjuvant chemoradiation may increase the risk of respiratory complications and sepsis after transthoracic esophagectomy.新辅助放化疗可能会增加经胸段食管癌切除术后发生呼吸并发症和脓毒症的风险。
J Thorac Cardiovasc Surg. 2006 Sep;132(3):549-55. doi: 10.1016/j.jtcvs.2006.05.015.
3
Induction therapy does not increase surgical morbidity after esophagectomy for cancer.诱导治疗不会增加食管癌切除术后的手术并发症发生率。
Ann Thorac Surg. 2004 Nov;78(5):1783-9. doi: 10.1016/j.athoracsur.2004.04.081.
4
Treatment of localized esophageal cancer.局限性食管癌的治疗
Semin Oncol. 2004 Aug;31(4):554-65. doi: 10.1053/j.seminoncol.2004.04.015.
5
Effects of preoperative chemoradiotherapy on postsurgical morbidity and mortality in cT3-4 +/- cM1lymph cancer of the oesophagus and gastro-oesophageal junction.术前放化疗对cT3-4 +/- cM1期食管癌和食管胃交界部癌术后发病率和死亡率的影响
Eur J Cardiothorac Surg. 2003 Aug;24(2):179-86; discussion 186. doi: 10.1016/s1010-7940(03)00274-4.
6
A meta-analysis of randomized controlled trials that compared neoadjuvant chemoradiation and surgery to surgery alone for resectable esophageal cancer.一项针对可切除食管癌的随机对照试验的荟萃分析，该分析比较了新辅助放化疗联合手术与单纯手术的疗效。
Am J Surg. 2003 Jun;185(6):538-43. doi: 10.1016/s0002-9610(03)00066-7.
7
Postesophagectomy morbidity, mortality, and length of hospital stay after preoperative chemoradiation therapy.术前放化疗后食管切除术后的发病率、死亡率及住院时间。
Ann Thorac Surg. 2002 Jul;74(1):227-31; discussion 231. doi: 10.1016/s0003-4975(02)03655-x.
8
Pulmonary complications after esophagectomy.食管癌切除术后的肺部并发症。
Ann Thorac Surg. 2002 Mar;73(3):922-6. doi: 10.1016/s0003-4975(01)03584-6.
9
Histologic tumor type is an independent prognostic parameter in esophageal cancer: lessons from more than 1,000 consecutive resections at a single center in the Western world.组织学肿瘤类型是食管癌的一个独立预后参数：来自西方世界一个单一中心连续1000多例切除术的经验教训。
Ann Surg. 2001 Sep;234(3):360-7; discussion 368-9. doi: 10.1097/00000658-200109000-00010.
10
Preoperative chemoradiotherapy for esophageal cancer.
J Clin Oncol. 2001 Jan 15;19(2):283-5. doi: 10.1200/JCO.2001.19.2.283.

新辅助放化疗对食管癌食管切除术患者气道定植及术后呼吸并发症的影响。

The effect of neoadjuvant chemoradiotherapy on airway colonization and postoperative respiratory complications in patients undergoing oesophagectomy for oesophageal cancer.

作者信息

Bagheri Reza, RajabiMashhadi Mohammad Taghi, Ghazvini Kiyarash, Asnaashari Amir, Zahediyan Ali, Sahebi Mehdi Abasi

机构信息

Endoscopic and Minimally Invasive Surgery Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

Interact Cardiovasc Thorac Surg. 2012 Jun;14(6):725-8. doi: 10.1093/icvts/ivs009. Epub 2012 Mar 5.

DOI:10.1093/icvts/ivs009
PMID:22392934
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3352705/
Abstract

Respiratory complication is one of the important postoperative complications of oesophageal cancer. The aim of this study was to evaluate whether neoadjuvant chemotherapy before surgery is effective for postoperative respiratory complications. In this study, patients with oesophageal cancer were divided into two group: one with neoadjuvant therapy and the other without neoadjuvant therapy. Before surgery, they all underwent bronchoscopy and bronchoalveolar lavage. We evaluated respiratory complications and the effects of preoperative neoadjuvant therapy. Forty patients (M/F = 23/17 and mean age 61 years) were enrolled in this study. Twenty-two cases had cancer in the middle part and 18 in the lower part of the oesophagus. Significant correlation was observed between the number of positive micro-organism and difficulty in weaning and receiving neoadjuvant therapy. But no significant correlation was found between neoadjuvant therapy and respiratory complications.

摘要

呼吸并发症是食管癌重要的术后并发症之一。本研究的目的是评估术前新辅助化疗对术后呼吸并发症是否有效。在本研究中，食管癌患者被分为两组：一组接受新辅助治疗，另一组未接受新辅助治疗。手术前，他们均接受了支气管镜检查和支气管肺泡灌洗。我们评估了呼吸并发症及术前新辅助治疗的效果。本研究共纳入40例患者（男/女=23/17，平均年龄61岁）。22例患者癌症位于食管中段，18例位于食管下段。微生物阳性数量与脱机困难及接受新辅助治疗之间存在显著相关性。但新辅助治疗与呼吸并发症之间未发现显著相关性。