低丙种球蛋白血症患者的恶性贫血。

Pernicious anemia in a patient with hypogammaglobulinemia.

作者信息

Moriuchi H, Takayanagi T, Yamasaki S, Yasui M, Mori K, Yanai M, Yanagi T, Tsuji Y

机构信息

Division of Pediatrics, Sasebo Kyosai Hospital, Japan.

出版信息

Acta Paediatr Jpn. 1990 Jun;32(3):311-4. doi: 10.1111/j.1442-200x.1990.tb00830.x.

DOI:10.1111/j.1442-200x.1990.tb00830.x

PMID:2239305

Abstract

A 19-year-old male with pernicious anemia and hypogammaglobulinemia (common variable immunodeficiency: CVID) is reported in comparison with classical pernicious anemia. This case was characterized by an earlier onset of anemia, the absence of autoantibodies to intrinsic factor or gastric parietal cells and involvement of the pyloric antrum as well as the gastric corpus. It is suggested that dysregulation of cellular immunity produces the autoimmune lesion in the gastric mucosa, including the pyloric antrum, in a patient with CVID, and that some of such cases develop pernicious anemia.

摘要

报告了一名19岁患有恶性贫血和低丙种球蛋白血症（常见变异型免疫缺陷：CVID）的男性，并与经典恶性贫血进行了比较。该病例的特点是贫血发病较早，缺乏针对内因子或胃壁细胞的自身抗体，且幽门窦和胃体均受累。提示细胞免疫失调在CVID患者的胃黏膜（包括幽门窦）产生自身免疫性病变，且其中一些病例会发展为恶性贫血。