Department of Medicine, College of Medicine, Taibah University, al-Madinah al-Munawarah, Kingdom of Saudi Arabia.
Int J Gen Med. 2012;5:143-9. doi: 10.2147/IJGM.S27373. Epub 2012 Feb 22.
Coronary heart disease is highly prevalent and a major cause of morbidity and mortality in diabetic patients. The aim of this study was to assess the major risk factors and their predictor score for coronary heart diseases in diabetic patients.
The present study was conducted in al-Madinah, Kingdom of Saudi Arabia. Using a cross-sectional case control study, 262 outpatient diabetics and 264 matched control subjects were examined for the risk factors and risk predictor scores for ischemic heart disease. The mean age of the patient and control groups was 49.61 ± 12.93 years and 48.39 ± 11.60 years, respectively.
Diabetic patients had significantly higher positive family history of diabetes, but no significant difference regarding their family history of hypertension. There was a significantly higher body mass index (33.67 kg/m(2)), glycosylated hemoglobin (7.26%), significantly higher cholesterol, low-density lipoprotein, and triglyceride in diabetics compared to control. Diabetic patients had higher risk for developing coronary heart disease with a mean risk score of 6.07 while the control subject risk score was -6.81. However, females showed significantly higher risk for coronary heart diseases than did males.
Our study replicates the known fact of higher risk in diabetes, but higher risk of coronary heart disease in female diabetics compared with male diabetics.
冠心病在糖尿病患者中发病率高，是导致其发病率和死亡率的主要原因之一。本研究旨在评估糖尿病患者冠心病的主要危险因素及其预测评分。
本研究在沙特阿拉伯麦地那进行。采用横断面病例对照研究，对 262 例门诊糖尿病患者和 264 例匹配对照者进行缺血性心脏病的危险因素和风险预测评分检查。患者组和对照组的平均年龄分别为 49.61 ± 12.93 岁和 48.39 ± 11.60 岁。
糖尿病患者阳性糖尿病家族史显著更高，但高血压家族史无显著差异。与对照组相比，糖尿病患者的体质指数（33.67 kg/m²）、糖化血红蛋白（7.26%）、胆固醇、低密度脂蛋白和甘油三酯更高。糖尿病患者发生冠心病的风险更高，平均风险评分 6.07，而对照组风险评分为-6.81。然而，女性发生冠心病的风险明显高于男性。
本研究证实了糖尿病患者风险较高的已知事实，但与男性糖尿病患者相比，女性糖尿病患者发生冠心病的风险更高。
