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Gene-environment interactions in obesity.肥胖中的基因-环境相互作用。
Forum Nutr. 2010;63:195-203. doi: 10.1159/000264407. Epub 2009 Nov 27.
2
Functional brown adipose tissue in healthy adults.健康成年人中的功能性棕色脂肪组织。
N Engl J Med. 2009 Apr 9;360(15):1518-25. doi: 10.1056/NEJMoa0808949.
3
Identification and importance of brown adipose tissue in adult humans.成人棕色脂肪组织的识别及其重要性。
N Engl J Med. 2009 Apr 9;360(15):1509-17. doi: 10.1056/NEJMoa0810780.
4
Cold-activated brown adipose tissue in healthy men.健康男性体内的冷激活棕色脂肪组织
N Engl J Med. 2009 Apr 9;360(15):1500-8. doi: 10.1056/NEJMoa0808718.
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WHO recognition of the global obesity epidemic.世界卫生组织对全球肥胖流行情况的认可。
Int J Obes (Lond). 2008 Dec;32 Suppl 7:S120-6. doi: 10.1038/ijo.2008.247.
6
The common -55 C/T polymorphism in the promoter region of the uncoupling protein 3 gene reduces prevalence of obesity and elevates serum high-density lipoprotein cholesterol levels in the general Japanese population.解偶联蛋白3基因启动子区域常见的-55C/T多态性降低了日本普通人群肥胖症的患病率，并提高了血清高密度脂蛋白胆固醇水平。
Metabolism. 2008 Mar;57(3):410-5. doi: 10.1016/j.metabol.2007.10.019.
7
Relationship between A-3826G polymorphism in the promoter of the uncoupling protein-1 gene and high-density lipoprotein cholesterol in Japanese individuals: a cross-sectional study.解偶联蛋白-1基因启动子区A-3826G多态性与日本人群高密度脂蛋白胆固醇的关系：一项横断面研究。
Arch Med Res. 2008 Jan;39(1):142-6. doi: 10.1016/j.arcmed.2007.07.002. Epub 2007 Oct 15.
8
Diagnostic criteria for dyslipidemia. Executive summary of Japan Atherosclerosis Society (JAS) guideline for diagnosis and prevention of atherosclerotic cardiovascular diseases for Japanese.血脂异常的诊断标准。日本动脉粥样硬化协会（JAS）日本动脉粥样硬化性心血管疾病诊断与预防指南执行摘要。
J Atheroscler Thromb. 2007 Aug;14(4):155-8. doi: 10.5551/jat.e537.
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HDL-c is a powerful lipid predictor of cardiovascular diseases.高密度脂蛋白胆固醇是心血管疾病的一种重要脂质预测指标。
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10
Association of UCP2 and UCP3 gene polymorphisms with serum high-density lipoprotein cholesterol among Korean women.韩国女性中UCP2和UCP3基因多态性与血清高密度脂蛋白胆固醇的关联
Metabolism. 2007 Jun;56(6):806-13. doi: 10.1016/j.metabol.2007.01.023.

解偶联蛋白-1基因A-3826G多态性与日本普通人群高密度脂蛋白胆固醇之间的关联：对肥胖状况的考量

The Association Between the Uncoupling Protein-1 Gene A-3826G Polymorphism and High-density Lipoprotein Cholesterol in A General Japanese Population: A Consideration of the Obesity Status.

作者信息

Kotani Kazuhiko, Fujiwara Shinji, Tsuzaki Kokoro, Sano Yoshiko, Nagai Narumi, Yamada Toshiyuki, Sakane Naoki

机构信息

Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.

出版信息

J Clin Med Res. 2011 Dec;3(6):319-24. doi: 10.4021/jocmr738w. Epub 2011 Nov 10.

DOI:10.4021/jocmr738w
PMID:22393344
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3279477/
Abstract

BACKGROUND

Limited studies have shown inconsistent data about the association between the uncoupling protein 1 (UCP1) gene A-3826G polymorphism and high-density lipoprotein (HDL) cholesterol levels. The present study investigated the association between the A-3826G polymorphism and low HDL-cholesterolemia in non-obese and obese subjects.

METHODS

Anthropometric and biochemical factors, in addition to genotyping by an allele-specific DNA assay, were measured in 294 community-dwelling Japanese subjects (male/female: 127/167, mean age: 65 years). Obesity was defined as a body mass index (BMI) ≥ 25 kg/m(2), and low HDL-cholesterolemia was defined as < 1.04 mmol/L of HDL-cholesterol.

RESULTS

The subjects with the G/G genotype (n = 27) showed a significantly higher prevalence of low HDL-cholesterolemia (37%) than those with the A/A + A/G genotype (13%) in the obese group (n = 102). There was a non-significant difference in the prevalence of low HDL-cholesterolemia between subjects with the G/G genotype (n = 45, 13%) and with the A/A + A/G genotype (15%) in the non-obese group (n = 192). A multivariate-adjusted logistic regression analysis of the presence of low HDL-cholesterolemia revealed that carrying the G/G genotype was an independent and significant factor positively associated with low HDL-cholesterolemia [odds ratio (OR): 6.85, 95% confidence interval (CI): 1.65-28.49] in the obese group, while carrying the G/G genotype exhibited a non-significant but reduced OR, by one-half, for low HDL-cholesterolemia (OR: 0.51, 95% CI: 0.13-1.96) in the non-obese group.

CONCLUSIONS

The obesity status could have opposing impacts on the relationship between the G/G genotype and low HDL-cholesterolemia, providing insight into the need to consider the obesity levels when studying the association between the UCP-1 gene A-3826G polymorphism and HDL-cholesterol.

KEYWORDS

Obesity; Body mass index; HDL-C; Atherosclerotic risk.

摘要

背景

有限的研究显示，关于解偶联蛋白1（UCP1）基因A-3826G多态性与高密度脂蛋白（HDL）胆固醇水平之间的关联，数据并不一致。本研究调查了A-3826G多态性与非肥胖和肥胖受试者低HDL胆固醇血症之间的关联。

方法

对294名居住在社区的日本受试者（男/女：127/167，平均年龄：65岁）进行了人体测量和生化指标检测，并通过等位基因特异性DNA检测进行基因分型。肥胖定义为体重指数（BMI）≥25kg/m²，低HDL胆固醇血症定义为HDL胆固醇<1.04mmol/L。

结果

在肥胖组（n = 102）中，G/G基因型受试者（n = 27）的低HDL胆固醇血症患病率（37%）显著高于A/A + A/G基因型受试者（13%）。在非肥胖组（n = 192）中，G/G基因型受试者（n = 45，13%）和A/A + A/G基因型受试者（15%）的低HDL胆固醇血症患病率无显著差异。对低HDL胆固醇血症存在情况进行多变量调整逻辑回归分析显示，在肥胖组中，携带G/G基因型是与低HDL胆固醇血症呈正相关的独立且显著因素[比值比（OR）：6.85，95%置信区间（CI）：1.65 - 28.49]，而在非肥胖组中，携带G/G基因型对低HDL胆固醇血症的OR虽无显著差异，但降低了一半（OR：0.51，95%CI：0.13 - 1.96）。

结论

肥胖状态可能对G/G基因型与低HDL胆固醇血症之间的关系产生相反影响，这为在研究UCP-1基因A-3826G多态性与HDL胆固醇之间的关联时考虑肥胖水平的必要性提供了见解。

关键词

肥胖；体重指数；HDL-C；动脉粥样硬化风险