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本文引用的文献

1
Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial.经鼻胰岛素治疗阿尔茨海默病和遗忘型轻度认知障碍：一项试点临床试验。
Arch Neurol. 2012 Jan;69(1):29-38. doi: 10.1001/archneurol.2011.233. Epub 2011 Sep 12.
2
The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.阿尔茨海默病所致轻度认知障碍的诊断：美国国家老龄化研究所-阿尔茨海默病协会诊断指南工作组的建议。
Alzheimers Dement. 2011 May;7(3):270-9. doi: 10.1016/j.jalz.2011.03.008. Epub 2011 Apr 21.
3
A phase II trial of huperzine A in mild to moderate Alzheimer disease.一项石杉碱甲治疗轻中度阿尔茨海默病的 II 期临床试验。
Neurology. 2011 Apr 19;76(16):1389-94. doi: 10.1212/WNL.0b013e318216eb7b.
4
Treatment with cholinesterase inhibitors and memantine of patients in the Alzheimer's Disease Neuroimaging Initiative.阿尔茨海默病神经影像倡议中患者使用胆碱酯酶抑制剂和美金刚的治疗情况。
Arch Neurol. 2011 Jan;68(1):58-66. doi: 10.1001/archneurol.2010.343.
5
PF-04494700, an oral inhibitor of receptor for advanced glycation end products (RAGE), in Alzheimer disease.PF-04494700，一种晚期糖基化终产物（RAGE）受体的口服抑制剂，用于治疗阿尔茨海默病。
Alzheimer Dis Assoc Disord. 2011 Jul-Sep;25(3):206-12. doi: 10.1097/WAD.0b013e318204b550.
6
Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial.二十二碳六烯酸补充剂与阿尔茨海默病认知能力下降：一项随机试验。
JAMA. 2010 Nov 3;304(17):1903-11. doi: 10.1001/jama.2010.1510.
7
Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial.B 族维生素降低同型半胱氨酸可减缓轻度认知障碍患者脑萎缩加速的速度：一项随机对照试验。
PLoS One. 2010 Sep 8;5(9):e12244. doi: 10.1371/journal.pone.0012244.
8
A randomized pilot clinical trial of the safety of pioglitazone in treatment of patients with Alzheimer disease.吡格列酮治疗阿尔茨海默病患者安全性的随机试点临床试验。
Arch Neurol. 2011 Jan;68(1):45-50. doi: 10.1001/archneurol.2010.229. Epub 2010 Sep 13.
9
Dimebon disappointment.盐酸美金刚胺令人失望。
Alzheimers Res Ther. 2010 Sep 13;2(5):25. doi: 10.1186/alzrt49.
10
Rosiglitazone monotherapy in mild-to-moderate Alzheimer's disease: results from a randomized, double-blind, placebo-controlled phase III study.罗格列酮单药治疗轻中度阿尔茨海默病的随机、双盲、安慰剂对照 III 期研究结果。
Dement Geriatr Cogn Disord. 2010;30(2):131-46. doi: 10.1159/000318845. Epub 2010 Aug 21.

阿尔茨海默病的有症状和非淀粉样蛋白/tau 相关的药物治疗。

Symptomatic and nonamyloid/tau based pharmacologic treatment for Alzheimer disease.

机构信息

University of California, San Diego, California 92093, USA.

出版信息

Cold Spring Harb Perspect Med. 2012 Mar;2(3):a006395. doi: 10.1101/cshperspect.a006395.

DOI:10.1101/cshperspect.a006395
PMID:22393531
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3282492/
Abstract

In this work we consider marketed drugs for Alzheimer disease (AD) including acetylcholinesterase inhibitors (AChE-Is) and antiglutamatergic treatment involving the N-methyl-d-aspartate (NMDA) receptor. We discuss medications and substances available for use as cognitive enhancers that are not approved for AD or cognitive impairment, and other neurotransmitter-related therapies in development or currently being researched. We also review putative therapies that aim to slow disease progression by mechanisms not directly related to amyloid or tau.

摘要

在这项工作中，我们考虑了用于治疗阿尔茨海默病（AD）的已上市药物，包括乙酰胆碱酯酶抑制剂（AChE-Is）和涉及 N-甲基-D-天冬氨酸（NMDA）受体的抗谷氨酸治疗。我们讨论了可作为认知增强剂使用的、未获 AD 或认知障碍批准的药物和物质，以及其他正在开发或正在研究中的与神经递质相关的治疗方法。我们还回顾了通过与淀粉样蛋白或 tau 无关的机制来减缓疾病进展的潜在治疗方法。