Department of Cellular and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA; Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina 27599, USA; and McAllister Heart Institute, Chapel Hill, North Carolina 27599, USA.
Cold Spring Harb Perspect Med. 2012 Mar;2(3):a006536. doi: 10.1101/cshperspect.a006536.
The vascular endothelium is a dynamic cellular "organ" that controls passage of nutrients into tissues, maintains the flow of blood, and regulates the trafficking of leukocytes. In tumors, factors such as hypoxia and chronic growth factor stimulation result in endothelial dysfunction. For example, tumor blood vessels have irregular diameters; they are fragile, leaky, and blood flow is abnormal. There is now good evidence that these abnormalities in the tumor endothelium contribute to tumor growth and metastasis. Thus, determining the biological basis underlying these abnormalities is critical for understanding the pathophysiology of tumor progression and facilitating the design and delivery of effective antiangiogenic therapies.
血管内皮是一种动态的细胞“器官”，它控制营养物质进入组织的通道，维持血液的流动，并调节白细胞的运输。在肿瘤中，缺氧和慢性生长因子刺激等因素导致内皮功能障碍。例如，肿瘤血管的直径不规则；它们脆弱、渗漏，血流异常。现在有充分的证据表明，肿瘤内皮的这些异常有助于肿瘤的生长和转移。因此，确定这些异常的生物学基础对于理解肿瘤进展的病理生理学和促进有效的抗血管生成治疗的设计和输送至关重要。
