Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
J Am Chem Soc. 2012 Mar 21;134(11):5056-9. doi: 10.1021/ja300697c. Epub 2012 Mar 8.
Asymmetric addition of arylboroxines to cyclic N-sulfonyl ketimines proceeded in the presence of a rhodium catalyst coordinated with a chiral diene ligand to give high yields of benzosultams, where a triaryl-substituted stereogenic carbon center was created with high enantioselectivity (93-99% ee). The chiral benzosultams were transformed into the chiral (triaryl)methylamines by breaking the cyclic structure.
在铑催化剂与手性二烯配体配位的存在下，芳基硼酸与环状 N-磺酰基亚胺进行不对称加成，以高产率得到苯并噻唑烷，其中三芳基取代的手性碳原子中心具有高对映选择性（93-99%ee）。通过破坏环状结构，手性苯并噻唑烷可转化为手性（三芳基）甲胺。
