Centre for Ophthalmology and Visual Science, and the ARC Centre of Excellence in Vision Science, The University of Western Australia, Perth, Western Australia, Australia.
Clin Exp Ophthalmol. 2012 Dec;40(9):881-7. doi: 10.1111/j.1442-9071.2012.02784.x. Epub 2012 May 17.
There is increasing evidence that relatively rapid spikes in intraocular pressure may contribute to axonal damage in glaucoma. The present study seeks to quantify the ability of a compressible damping element (a simple air bubble) to reduce intraocular pressure fluctuations induced by a known change in intraocular fluid volume.
A mathematical model describing the damping of intraocular pressure increases for a given infusion volume was developed and compared with experimental data obtained from isolated pig eyes. A damping element (100 µL to 2 mL of air) was added to the system, and the effect on the induced intraocular pressure change for a given infusion volume was assessed.
The introduction of the damping element reduced the intraocular pressure change in a volume-dependent manner consistent with the mathematical modelling. The maximum bubble size tested (2 mL) dampened the intraocular pressure change by an average of 63.5 ± 8.7% at a baseline pressure close to 20 mmHg. Close agreement was seen between the mathematical model and the experimental data.
Mathematical modelling and experiments in isolated pig eyes demonstrated that the addition of a damping element in the form of a compressible air bubble is capable of significantly reducing induced intraocular pressure spikes.
越来越多的证据表明，眼内压的相对快速波动可能导致青光眼的轴突损伤。本研究旨在定量评估可压缩阻尼元件（简单的气泡）降低已知眼内液体积变化引起的眼内压波动的能力。
我们建立了一个描述给定输注体积引起的眼内压升高的阻尼模型，并与从离体猪眼获得的实验数据进行了比较。在系统中添加一个阻尼元件（100µL 至 2mL 空气），并评估其对给定输注体积引起的眼内压变化的影响。
引入阻尼元件后，眼内压变化呈体积依赖性降低，与数学模型一致。测试的最大气泡尺寸（2mL）在接近 20mmHg 的基础压下平均将眼内压变化降低了 63.5±8.7%。数学模型与实验数据之间存在很好的一致性。
在离体猪眼的数学建模和实验中，我们证明了以可压缩气泡形式添加阻尼元件能够显著降低诱导的眼内压峰值。
