Laboratory of Cellular and Molecular Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892-0420, USA.
Cold Spring Harb Perspect Biol. 2012 Apr 1;4(4):a006908. doi: 10.1101/cshperspect.a006908.
A fundamental property of the immune system is its ability to mediate self-defense with a minimal amount of collateral damage to the host. The system uses several different mechanisms to achieve this goal, which is collectively referred to as the "process of immunological tolerance." This article provides an introductory historical overview to these various mechanisms, which are discussed in greater detail throughout this collection, and then briefly describes what happens when this process fails, a state referred to as "autoimmunity."
免疫系统的一个基本特性是，它能够在对宿主造成最小程度的附带损伤的情况下进行自我防御。该系统使用几种不同的机制来实现这一目标，这些机制统称为“免疫耐受过程”。本文对这些不同的机制进行了简要的历史回顾，这些机制在本专题中进行了更详细的讨论，然后简要描述了这个过程失败时会发生什么，即所谓的“自身免疫”。
