Department of Obstetrics and Gynecology, Hacettepe University, Ankara, Turkey.
Arch Gynecol Obstet. 2012 Jul;286(1):203-8. doi: 10.1007/s00404-012-2280-z. Epub 2012 Mar 7.
To investigate the prevalence of cervical human papilloma virus (HPV) with genotyping and simultaneous cervical cytology among Turkish women in a university hospital. A review of literature was done as well to summarize the results of similar Turkish studies based on hospital data.
Women who were subjected to cervical HPV-DNA testing with simultaneous cervical Pap test were included. Seeplex HPV 18-plex Genotyping Test was used for HPV detection and typing. Liquid-based cytology was used for Pap test and Bethesda system was used for results.
Study group included 890 patients with a mean age of 39.5 years. The prevalence of any HPV was 25.7% while high-risk HPV was positive in 23.0%. There were no significant differences in HPV prevalence between younger and older women. Among HPV-positive women, 89.5% had at least one type of high-risk HPV. Most common HPV was type 16 followed by type 31 and 51. Abnormal cervical cytology rate was 11.6%. Rate of HPV positivity was significantly higher in women with abnormal cervical cytology compared to women with normal cytology (54.4 vs. 22.0%).
Cervical HPV infection is a serious and gradually growing problem for Turkish women according to hospital-based data. This may be associated with low age at marriage and more sensitive HPV detection methods.
在一所大学医院中，通过基因分型和同时进行宫颈细胞学检查，调查土耳其女性中宫颈人乳头瘤病毒（HPV）的流行情况。同时对文献进行综述，总结基于医院数据的类似土耳其研究的结果。
纳入同时接受宫颈 HPV-DNA 检测和宫颈巴氏涂片检查的女性。采用 Seeplex HPV 18 型基因分型检测试剂盒进行 HPV 检测和分型。采用液基细胞学进行巴氏涂片检查，采用巴氏系统报告结果。
研究组包括 890 名平均年龄为 39.5 岁的患者。HPV 总感染率为 25.7%，高危型 HPV 感染率为 23.0%。年轻和年长女性的 HPV 感染率无显著差异。在 HPV 阳性的女性中，89.5%至少有一种高危型 HPV。最常见的 HPV 型别是 16 型，其次是 31 型和 51 型。异常宫颈细胞学的检出率为 11.6%。与细胞学正常的女性相比，细胞学异常的女性 HPV 阳性率显著更高（54.4% vs. 22.0%）。
根据医院数据，宫颈 HPV 感染是土耳其女性面临的一个严重且日益严重的问题。这可能与结婚年龄较早和 HPV 检测方法更敏感有关。
