Sasaki M, Kaneko Y
Department of Urology, Shizuoka City Hospital.
Hinyokika Kiyo. 1990 Aug;36(8):909-12; discussion 912-3.
To obtain objective information about bladder cancer, we measured the mean nuclear volume of bladder cancer cells by using the "Point Sampled Intercepts" method, which was published by Gundersen et al. Thirty one cases of bladder cancer were selected and divided into 2 groups: group A; no recurrence over 3 years after initial TUR (12 cases), group B; cystectomy or cancer death (19 cases). Estimated mean nuclear volume was significantly smaller in group A than in group B. It is suggested that estimation of the mean nuclear volume by this stereological method may provide objective information for predicting the prognosis of patients with bladder cancers. Further studies in additional patients are required to substantiate the predictive potential of this method.
为获取有关膀胱癌的客观信息，我们采用Gundersen等人发表的“点采样截距”法测量了膀胱癌细胞的平均核体积。选取31例膀胱癌患者并分为两组：A组，初次经尿道膀胱肿瘤切除术（TUR）后3年无复发（12例）；B组，膀胱切除术或癌症死亡（19例）。A组的估计平均核体积显著小于B组。提示通过这种体视学方法估计平均核体积可为预测膀胱癌患者的预后提供客观信息。需要对更多患者进行进一步研究以证实该方法的预测潜力。
