Sasaki M, Nakamura E, Kaneko Y
Department of Urology, Shizuoka City Hospital.
Hinyokika Kiyo. 1991 Jul;37(7):679-84.
The mean nuclear volume (MNV) of non-tumorous bladder mucosa in 27 patients with a bladder tumor was estimated by using a new stereological method, "vertical section". Eighty four specimens were obtained by punch biopsy from preselected sites of urinary bladder. Thirteen specimens (10 patients) out of 84 were histologically diagnosed as carcinoma in situ (CIS). Bladder mucosa of 24 patients with various benign diseases were also measured as normal controls. The MNV of the normal control group was 127.1 +/- 19.6 microns 3 (mean +/- standard error) and that of the specimens diagnosed with CIS was 279.6 +/- 69.0 microns 3. There was no overlap between the two groups. Out of 71 specimens diagnosed as having no malignancy, 30 (42.3%) exhibited significantly increased MNV. Estimation of the MNV of non-tumorous bladder mucosa may be useful for standardization of CIS. Further studies are needed to investigate the role of the increased MNV in histologically normal mucosa in the course of a bladder tumor.
采用一种新的体视学方法“垂直切片法”，对27例膀胱肿瘤患者的非肿瘤性膀胱黏膜的平均核体积（MNV）进行了估算。通过对膀胱预先选定部位进行打孔活检获取了84个标本。84个标本中有13个（10例患者）经组织学诊断为原位癌（CIS）。还对24例患有各种良性疾病患者的膀胱黏膜进行了测量作为正常对照。正常对照组的MNV为127.1±19.6立方微米（均值±标准误），诊断为CIS的标本的MNV为279.6±69.0立方微米。两组之间没有重叠。在71个诊断为无恶性病变的标本中，30个（42.3%）的MNV显著增加。非肿瘤性膀胱黏膜MNV的估算可能有助于CIS的标准化。需要进一步研究来探讨MNV增加在膀胱肿瘤病程中组织学正常黏膜中的作用。
