Mizuo T, Ohashi H, Tanizawa A, Okuno T
Department of Urology, Tokyo Rosai Hospital.
Hinyokika Kiyo. 1990 Aug;36(8):931-5.
A 68-year-old man with multiple pulmonary metastases from a right renal cell carcinoma was treated with alpha interferon, but there was no improvement. For this reason, alpha interferon was ceased, and daily monotherapy with recombinant interleukin-2 (1,000,000 units/day) was commenced. After 4 months, plain chest x-ray and chest CT revealed complete clearance of the pulmonary metastases. There were no side effects except general fatigue and slight fever. Immunological studies revealed elevation of the leukocyte count (lymphocytes, eosinophils) and enhancement natural killer activity. At 10 months after discontinuation of the drug, recurrence has not been observed. Our case indicates the potential value of interleukin-2 following treatment with alpha interferon.
一名68岁男性患有右肾细胞癌伴多发肺转移，接受了α干扰素治疗，但病情无改善。因此，停用α干扰素，开始每日使用重组白细胞介素-2进行单一疗法治疗（100万单位/天）。4个月后，胸部X线平片和胸部CT显示肺转移灶完全清除。除了全身疲劳和轻微发热外，没有其他副作用。免疫学研究显示白细胞计数（淋巴细胞、嗜酸性粒细胞）升高，自然杀伤活性增强。停药10个月后，未观察到复发。我们的病例表明了α干扰素治疗后使用白细胞介素-2的潜在价值。
