Oncology Biomarker Development/Pharmacodynamic Biomarkers, Genentech, Inc., South San Francisco, CA, USA.
Adv Exp Med Biol. 2012;728:183-94. doi: 10.1007/978-1-4614-0887-1_12.
Fibroblast growth factors (FGFs) and their cognate receptors, FGF receptors (FGFRs), play critical roles in a variety of normal developmental and physiological processes. Numerous reports support a role for deregulation of FGF-FGFR signaling, whether it is at the ligand and/or receptor level, in tumor development and progression. The FGF19-FGFR4 signaling axis has been implicated in the pathogenesis of several cancers, including hepatocellular carcinomas in mice and potentially in humans. This chapter focuses on recent progress in the understanding of the molecular mechanisms of FGF19 action and its potential involvement in cancer.
成纤维细胞生长因子 (FGFs) 及其同源受体 FGF 受体 (FGFRs) 在多种正常发育和生理过程中发挥着关键作用。大量报告支持 FGF-FGFR 信号失调在肿瘤发生和发展中的作用，无论是在配体和/或受体水平上。FGF19-FGFR4 信号轴已被牵连到几种癌症的发病机制中，包括小鼠的肝细胞癌，可能还包括人类的肝细胞癌。本章重点介绍了对 FGF19 作用的分子机制及其在癌症中潜在作用的理解方面的最新进展。
