Departemnt of Cardiology, The Catholic University of Korea College of Medicine, Seoul, Korea.
Korean Circ J. 2012 Feb;42(2):100-6. doi: 10.4070/kcj.2012.42.2.100. Epub 2012 Feb 27.
Thrombospondin-1 (TSP-1) is associated with atherosclerosis in animals with diabetes mellitus (DM). But, no study has investigated the role of TSP-1 in human atherosclerosis. This study investigated the relationship among plasma TSP-1 concentration, DM, and coronary artery disease (CAD).
The study involved 374 consecutive subjects with suspected CAD, who had undergone coronary angiography to evaluate effort angina. Patients were divided into four groups as follows: DM(-) and CAD(-), DM(-) and CAD(+), DM(+) and CAD(-), and DM (+) and CAD(+).
We found that plasma TSP-1 levels were higher in patients with DM(+) and CAD(+) (n=103) than those in other patients (n=271) (p<0.01). A multivariate analysis showed that male gender {odds ratio (OR), 2.728; 95% confidence interval (CI), 1.035-7.187}, high density lipoprotein-cholesterol (OR, 0.925; 95% CI, 0.874-0.980), glycated hemoglobin (OR, 1.373; 95% CI, 1.037-1.817), and plasma TSP-1 (OR, 1.004; 95% CI, 1.000-1.008) levels were independently associated with the presence of CAD in patients with DM.
Plasma TSP-1 levels were higher in patients with DM(+) and CAD(+) than those in other patients, and plasma TSP-1 levels were independently associated with the presence of CAD in patients with DM. These findings show a possible link between human plasma TSP-1 concentration and CAD in patients with DM.
血小板反应蛋白-1（TSP-1）与糖尿病（DM）动物的动脉粥样硬化有关。但是，尚无研究调查 TSP-1 在人类动脉粥样硬化中的作用。本研究调查了血浆 TSP-1 浓度、DM 和冠状动脉疾病（CAD）之间的关系。
本研究涉及 374 例连续疑似 CAD 的患者，这些患者接受了冠状动脉造影以评估劳力性心绞痛。患者分为以下四组：DM（-）和 CAD（-）、DM（-）和 CAD（+）、DM（+）和 CAD（-）以及 DM（+）和 CAD（+）。
我们发现，DM（+）和 CAD（+）患者（n=103）的血浆 TSP-1 水平高于其他患者（n=271）（p<0.01）。多变量分析显示，男性（优势比 [OR]，2.728；95%置信区间 [CI]，1.035-7.187）、高密度脂蛋白胆固醇（OR，0.925；95%CI，0.874-0.980）、糖化血红蛋白（OR，1.373；95%CI，1.037-1.817）和血浆 TSP-1（OR，1.004；95%CI，1.000-1.008）水平与 DM 患者 CAD 的存在独立相关。
DM（+）和 CAD（+）患者的血浆 TSP-1 水平高于其他患者，并且血浆 TSP-1 水平与 DM 患者 CAD 的存在独立相关。这些发现表明人类血浆 TSP-1 浓度与 DM 患者 CAD 之间可能存在联系。
