Gruber Hannes, Loizides Alexander, Peer Siegfried, Gruber Ingrid
Innsbruck Medical University, Department of Radiology, Innsbruck, Austria.
Med Ultrason. 2012 Mar;14(1):5-9.
The currently accepted pathophysiological concept behind median arcuate ligament syndrome (MALS) is vascular compromise by atypically positioned median arcuate ligament. Despite many articles on MALS, only sparse data on the outcome in general and the rather poor outcome after intervention have been reported and this makes at least questionable the current concepts of the underlying disease.
A total of 364 patients with suspected celiac trunk pathology underwent a standardized ultrasound assessment procedure: suspected diagnostic features for MALS such as typically elevated peak flow velocities (PV) in the celiac trunk or atypical celiac trunk deflection-angles (DA) were defined in patients and in 20 matched volunteers.
All the 6 retrospectively clearly diagnosed MALS-patients as well as 40% (8/20) of volunteers presented a DA of over 50°. MALS-patients presented a mean inspiratory PV of 172cm/s (+/- 40.9 cm/s), a mean expiratory PV of 425cm/s (+/-130.1 cm/s) with a PV-amplitude of 249.1% (+/-68.9%). Volunteers presented a mean inspiratory PV of 126.9cm/s (+/-42 cm/s), a mean expiratory PV of 209.9cm/s (+/-80.1 cm/s) with a PV-amplitude of 169.4% (+/-54.3%).
The combination of a maximum expiratory PV of over 350 cm/s and a DA higher than 50° seems to be a most reliable indicator for MALS in this small series of patients. Based on these data we propose that functional ultrasound should be the first line in screening for MALS. However, a clear pathophysiological definition of MALS remains still obscure.
目前关于正中弓状韧带综合征(MALS)被广泛接受的病理生理概念是,异常位置的正中弓状韧带导致血管受压。尽管有许多关于MALS的文章,但总体上关于其结果以及干预后相当糟糕的结果的报道数据却很少,这至少让人对当前潜在疾病的概念产生质疑。
总共364例疑似腹腔干病变的患者接受了标准化超声评估程序:在患者和20名匹配的志愿者中定义了MALS的疑似诊断特征,如腹腔干中典型的峰值流速(PV)升高或腹腔干非典型偏转角(DA)。
所有6例经回顾性明确诊断为MALS的患者以及40%(8/20)的志愿者的DA超过50°。MALS患者吸气期平均PV为172cm/s(±40.9 cm/s),呼气期平均PV为425cm/s(±130.1 cm/s),PV振幅为249.1%(±68.9%)。志愿者吸气期平均PV为126.9cm/s(±42 cm/s),呼气期平均PV为209.9cm/s(±80.1 cm/s),PV振幅为169.4%(±54.3%)。
在这一小部分患者中,呼气期最大PV超过350 cm/s且DA高于50°的组合似乎是MALS最可靠的指标。基于这些数据,我们建议功能超声应作为MALS筛查的一线方法。然而,MALS明确的病理生理定义仍然不清楚。