Kackov Sanja, Simundić Ana-Maria, Nikolac Nora, Bilusić Marinko
Bonifarm Policlinic, Medical Biochemistry Laboratory, Zagreb, Croatia.
Coll Antropol. 2011 Dec;35(4):1055-9.
Hyperuricemia may have an important role in metabolic syndrome, cardiovascular diseases and stroke. Elevated serum uric acid concentration has been shown to be the strong predictor of cardiovascular mortality in several recently published studies. Our aim was to determine the prevalence of hyperuricemia in general Croatian population and to investigate the association of serum uric acid with glucose and lipids. This was a retrospective cross-sectional study on 6,476 consecutive adults. Prevalence of hyperuricemia was 13.9% in general population and it was significantly higher in males, than in females (26% vs. 6%; p < 0.001). Median uric acid concentration was higher in males than in females (343 vs. 238 micromol/L; p < 0.001). Age, glucose and lipid parameters did not correlate with uric acid. In hyperuricemic subjects, increased concentrations of glucose (33.1% vs. 13.1%; p < 0.001), triglycerides (46.9% vs. 17.6%; p < 0.001), total cholesterol (69.6% vs. 51.9%; p < 0.001), LDL-cholesterol (64.5% vs. 46.4%; p < 0.001) and decreased concentration of HDL-cholesterol (24.3% vs. 13.0%; p < 0.001) were more prevalent than in subjects with normal serum concentrations of uric acid. Hyperuricemia is highly prevalent in Croatian general population and it aggregates with hyperglycemia and dyslipidemia.
高尿酸血症可能在代谢综合征、心血管疾病和中风中起重要作用。最近发表的几项研究表明，血清尿酸浓度升高是心血管疾病死亡率的有力预测指标。我们的目的是确定克罗地亚普通人群中高尿酸血症的患病率，并研究血清尿酸与血糖和血脂的关系。这是一项对6476名连续成年患者进行的回顾性横断面研究。普通人群中高尿酸血症的患病率为13.9%，男性显著高于女性（26%对6%；p<0.001）。男性的尿酸中位数浓度高于女性（343对238微摩尔/升；p<0.001）。年龄、血糖和血脂参数与尿酸无关。在高尿酸血症患者中，血糖（33.1%对13.1%；p<0.001）、甘油三酯（46.9%对17.6%；p<0.001）、总胆固醇（69.6%对51.9%；p<0.001）、低密度脂蛋白胆固醇（64.5%对46.4%；p<0.001）浓度升高以及高密度脂蛋白胆固醇浓度降低（24.3%对13.0%；p<0.001）的情况比血清尿酸浓度正常的患者更为普遍。高尿酸血症在克罗地亚普通人群中非常普遍，并且与高血糖和血脂异常聚集在一起。
