Akbas Emin Murat, Timuroglu Aysu, Ozcicek Adalet, Ozcicek Fatih, Demirtas Levent, Gungor Adem, Akbas Nergis
Department of Endocrinology, Mengücek Gazi Training and Research Hospital, School of Medicine, Erzincan University Erzincan, Turkey.
Department of Internal Medicine, Mengücek Gazi Training and Research Hospital, School of Medicine, Erzincan University Erzincan, Turkey.
Int J Clin Exp Med. 2014 Dec 15;7(12):5737-43. eCollection 2014.
The associations of serum uric acid (UA), atherogenic index of plasma (AIP) and albuminuria with cardiovascular disease have been shown. Several studies focused on association of serum UA and dyslipidemia, serum UA and renal impairment, dyslipidemia and renal impairment. However, to date, in literature, there have been no studies demonstrating the relationship between these parameters in diabetic patients together.
We aimed to investigate the association between serum UA, albuminuria and AIP in diabetic patients.
This was a retrospective study involving data of 645 diabetic patients. The patients were separated into groups according to their serum uric acid and AIP levels. The quantitative urine albumin/creatinine ratio in morning spot urine samples were used for standard albuminuria determination. Serum uric acid levels under 6 mg/dL were considered as normal. AIP was calculated as the logarithmically transformed ratio of triglyceride to high density lipoprotein cholesterol.
AIP and albuminuria levels were high in high serum UA group compared to normal UA group. Uric acid and albuminuria tended to increase with increasing AIP. Correlation analysis showed that albuminuria, AIP and UA were significantly correlated with each other. Additionally, in binary logistic regression analysis, AIP was found to be independently associated with high UA levels.
Present study reveals that serum UA, AIP and albuminuria are closely related. Physicians should be aware that patients with concomitant hyperuricemia, albuminuria and high AIP are at increased risk of developing cardiovascular disease. Our study confirms that there is a need for larger prospective studies to determine the mechanisms underlying the association of serum UA, AIP and albuminuria.
血清尿酸（UA）、血浆致动脉粥样硬化指数（AIP）和蛋白尿与心血管疾病之间的关联已得到证实。多项研究聚焦于血清尿酸与血脂异常的关联、血清尿酸与肾功能损害的关联以及血脂异常与肾功能损害的关联。然而，迄今为止，文献中尚无研究同时证明这些参数在糖尿病患者中的关系。
我们旨在研究糖尿病患者血清尿酸、蛋白尿与AIP之间的关联。
这是一项回顾性研究，纳入了645例糖尿病患者的数据。根据患者的血清尿酸和AIP水平将其分组。采用晨尿样本中尿白蛋白/肌酐的定量比值来测定标准蛋白尿。血清尿酸水平低于6mg/dL被视为正常。AIP的计算方法是甘油三酯与高密度脂蛋白胆固醇的对数转换比值。
与正常尿酸组相比，高血清尿酸组的AIP和蛋白尿水平较高。尿酸和蛋白尿倾向于随着AIP的升高而增加。相关性分析表明，蛋白尿、AIP和尿酸之间存在显著相关性。此外，在二元逻辑回归分析中，发现AIP与高尿酸水平独立相关。
本研究表明血清尿酸、AIP和蛋白尿密切相关。医生应意识到，同时伴有高尿酸血症、蛋白尿和高AIP的患者发生心血管疾病的风险增加。我们的研究证实，需要进行更大规模的前瞻性研究来确定血清尿酸、AIP和蛋白尿之间关联的潜在机制。
