Grzybowska-Szatkowska Ludmila, Slaska Brygida
Department of Oncology, Medical University of Lublin, Jaczewskiego 7, 20-090 Lublin, Poland.
Mitochondrial DNA. 2012 Apr;23(2):106-11. doi: 10.3109/19401736.2012.660925. Epub 2012 Mar 7.
Recently, there have been indications of participation of mitochondria in the carcinogenic process and the role of polymorphisms in increasing the risk of cancer. The aim of the study was to detect possible changes in the sequence of 22 genes encoding mitochondrial tRNA in breast cancer carcinoma, which take part in protein synthesis in the translation process. The analysis of tumour tissue and blood material sampled from 50 patients revealed that few mutations have been found. It cannot be excluded that, through their impact on the secondary and tertiary tRNA structure, polymorphisms may cause mitochondrial dysfunction and contribute to appearance of other changes in mtDNA. Mutations in tRNA genes in breast cancer may affect the cell and cause its dysfunction, as in mitochondrial diseases.
最近，有迹象表明线粒体参与致癌过程以及基因多态性在增加癌症风险中的作用。本研究的目的是检测乳腺癌中参与翻译过程蛋白质合成的22个编码线粒体tRNA的基因序列可能发生的变化。对50例患者的肿瘤组织和血液样本进行分析后发现，几乎未发现突变。不能排除多态性通过影响tRNA的二级和三级结构，可能导致线粒体功能障碍并促使线粒体DNA出现其他变化。乳腺癌中tRNA基因的突变可能像在线粒体疾病中那样影响细胞并导致其功能障碍。
