Department of Clinical Pharmacology, Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, People's Republic of China.
Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, 410078, People's Republic of China.
J Exp Clin Cancer Res. 2018 May 9;37(1):101. doi: 10.1186/s13046-018-0745-z.
Transfer RNAs (tRNAs), traditionally considered to participate in protein translation, were interspersed in the entire genome. Recent studies suggested that dysregulation was observed in not only tRNAs, but also tRNA derivatives generated by the specific cleavage of pre- and mature tRNAs in the progression of cancer. Accumulating evidence had identified that certain tRNAs and tRNA derivatives were involved in proliferation, metastasis and invasiveness of cancer cell, as well as tumor growth and angiogenesis in several malignant human tumors. This paper reviews the importance of the dysregulation of tRNAs and tRNA derivatives during the development of cancer, such as breast cancer, lung cancer, and melanoma, aiming at a better understanding of the tumorigenesis and providing new ideas for the treatment of these cancers.
转移 RNA（tRNA），传统上被认为参与蛋白质翻译，在整个基因组中分布。最近的研究表明，不仅 tRNA，而且前体和成熟 tRNA 特定切割产生的 tRNA 衍生物在癌症进展中也存在失调。越来越多的证据表明，某些 tRNA 和 tRNA 衍生物参与了癌细胞的增殖、转移和侵袭，以及几种恶性人类肿瘤的肿瘤生长和血管生成。本文综述了 tRNA 和 tRNA 衍生物在乳腺癌、肺癌和黑色素瘤等癌症发展过程中失调的重要性，旨在更好地理解肿瘤发生，并为这些癌症的治疗提供新的思路。
