Institute of Epidemiology, Danish Cancer Society, Copenhagen, Denmark.
Acta Oncol. 2012 Apr;51(4):454-64. doi: 10.3109/0284186X.2011.636754. Epub 2012 Mar 8.
A number of epidemiological studies have examined the association between use of dairy products and risk of ovarian cancer, but results are conflicting. Using data from a large Danish population-based case-control study we here further examined the association between dairy consumption, lactose, and calcium and risk of overall ovarian cancer and histological types of ovarian cancer.
In the period 1995-1999 we included 554 women with epithelial ovarian cancer and 1554 randomly selected age-matched controls (35-79 years). All women participated in a detailed personal interview that included questions about dairy consumption. Data were analysed using multiple logistic regression models.
Total dairy intake was associated with ovarian cancer risk (OR = 1.11; 95% CI: 1.07-1.15 per 100 ml/day). The association was strongest for milk [OR = 1.14; 95% CI: 1.03-1.27 per glass (200 ml)/day], soured milk products [OR = 1.49; 95% CI: 1.22-1.81 per portion (250 ml)/day] and yoghurt [OR = 1.65; 95% CI: 1.22-2.23 per portion (250 ml)/day]. In contrast, intake of cheese was associated with a decreased risk [OR = 0.70; 95% CI: 0.55-0.89 for > 1 portion (100 ml)/day compared with no intake]. Intake of lactose, but not calcium, was also associated with an increased ovarian cancer risk (OR = 1.24; 95% CI: 1.10-1.40 per 10 g of lactose/day). Similar risk patterns were observed for the different histological types of ovarian cancer, indicating virtually identical aetiologies with regard to dairy intake, lactose, and calcium.
Our results indicate that intake of dairy products is associated with a modest increased risk of ovarian cancer. In addition, ovarian cancer development was associated with lactose intake.
多项流行病学研究已经研究了乳制品的使用与卵巢癌风险之间的关系，但结果存在争议。使用来自丹麦大型基于人群的病例对照研究的数据，我们进一步研究了乳制品摄入、乳糖和钙与总体卵巢癌和卵巢癌组织类型风险之间的关系。
在 1995-1999 年期间，我们纳入了 554 名上皮性卵巢癌患者和 1554 名年龄匹配的随机对照者（35-79 岁）。所有女性均参与了详细的个人访谈，其中包括有关乳制品摄入的问题。使用多变量逻辑回归模型分析数据。
总乳制品摄入量与卵巢癌风险相关（OR = 1.11；95%CI：100 ml/天增加 1 份，1.07-1.15）。与牛奶的相关性最强[OR = 1.14；95%CI：每杯（200 ml）增加 1 份，1.03-1.27]、酸奶产品[OR = 1.49；95%CI：每 250 ml 份增加 1 份，1.22-1.81]和酸奶[OR = 1.65；95%CI：每 250 ml 份增加 1 份，1.22-2.23]。相比之下，摄入奶酪与降低的风险相关[OR = 0.70；95%CI：与不摄入相比，每天摄入 > 1 份（100 ml）时，0.55-0.89]。乳糖的摄入而不是钙的摄入也与卵巢癌风险增加相关（OR = 1.24；95%CI：10 g 乳糖/天增加 1.10-1.40）。不同卵巢癌组织类型也观察到类似的风险模式，表明乳制品摄入、乳糖和钙与卵巢癌的发病机制几乎相同。
我们的研究结果表明，乳制品的摄入与卵巢癌的风险略有增加相关。此外，卵巢癌的发展与乳糖摄入有关。
