Centre of Research and Promotion of Women's Health, School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR.
Nutr Cancer. 2011;63(1):12-20. doi: 10.1080/01635581.2010.516478.
The results of dairy food consumption and breast cancer risk are conflicting, and their relationship has not previously been studied in China. The objective of this study is to examine the association between dairy products, calcium intake, and breast cancer risk among Chinese women. A hospital-based case-control study was conducted among Chinese women in the Guangdong province from June 2007 to August 2008. Four hundred and thirty-eight consecutively recruited cases with primary breast cancer were frequency-matched to 438 controls on age and residence. Dietary intake information was collected by interviewers using a validated food frequency questionnaire. Odds ratios (ORs) and 95% confidence interval (CI) were estimated using unconditional multiple logistic regression adjusted for various potential confounders. We observed a statistically significant inverse association of dietary calcium intake with breast cancer risk, with the adjusted OR (95% CI) of 0.35 (0.22-0.56) comparing the highest with the lowest quartile. No significant association was found between dairy products measured either by dry weight of dairy product or dairy product protein intake and breast cancer risk. Our study supports a protective effect of high intake of dietary calcium on breast cancer risk, and no association with dairy product intake.
乳制品消费与乳腺癌风险的关系结果相互矛盾，且此前尚未在中国人群中进行过研究。本研究旨在探讨中国女性中乳制品、钙摄入量与乳腺癌风险之间的关系。本病例对照研究于 2007 年 6 月至 2008 年 8 月在广东省进行，共纳入 438 例连续招募的原发性乳腺癌病例，并按年龄和居住地与 438 名对照进行频数匹配。通过经过验证的食物频率问卷，由调查员收集膳食摄入信息。采用非条件多因素 logistic 回归模型，调整了各种潜在混杂因素后，计算比值比（ORs）及其 95%置信区间（CIs）。我们发现，膳食钙摄入量与乳腺癌风险呈显著负相关，最高四分位数与最低四分位数相比，调整后的 OR（95%CI）为 0.35（0.22-0.56）。我们未发现乳制品（按干重或乳制品蛋白摄入量衡量）与乳腺癌风险之间存在显著关联。本研究支持高钙摄入量对乳腺癌风险有保护作用，与乳制品摄入无关。
