采用苯酚进行深层焕肤与三氯乙酸 20%联合进行经皮胶原诱导治疗痤疮后萎缩性瘢痕：一项随机对照试验。
Deep peeling using phenol versus percutaneous collagen induction combined with trichloroacetic acid 20% in atrophic post-acne scars; a randomized controlled trial.
机构信息
Department of Dermatology, Faculty of Medicine, Cairo University , Cairo , Egypt.
出版信息
J Dermatolog Treat. 2014 Apr;25(2):130-6. doi: 10.3109/09546634.2012.674192. Epub 2012 May 8.
BACKGROUND
Deep peeling using phenol and percutaneous collagen induction (PCI) are used in treating acne scars.
AIM
To compare deep peeling using phenol and PCI combined with trichloroacetic acid (TCA) 20% in treating atrophic acne scars.
METHODS
24 patients with post-acne atrophic scars were randomly divided into two groups; group 1 was subjected to one session of deep peeling using phenol, and group 2 was subjected to four sessions of PCI combined with TCA 20%. As a secondary outcome measure, side effects were recorded and patients were asked to assess their % of improvement by a questionnaire completed 8 months after the procedure.
RESULTS
Scar severity scores improved by a mean of 75.12% (p < 0.001) in group 1 and a mean of 69.43% (p < 0.001) in group 2. Comparing the degree of improvement in different types of scars, within the same group after treatment, revealed a significant highest degree of improvement in the rolling type (p = 0.005) in group 2.
CONCLUSION
Deep peeling using phenol and PCI with TCA 20% were effective in treating post-acne atrophic scars.
背景
使用苯酚和经皮胶原诱导（PCI）进行深层脱皮术可用于治疗痤疮疤痕。
目的
比较苯酚深层脱皮术和 PCI 联合 20%三氯乙酸（TCA）治疗萎缩性痤疮疤痕的效果。
方法
将 24 例痤疮后萎缩性疤痕患者随机分为两组；第 1 组接受 1 次苯酚深层脱皮术，第 2 组接受 4 次 PCI 联合 20%TCA。作为次要结局指标，记录不良反应，并在术后 8 个月通过问卷调查评估患者的改善百分比。
结果
第 1 组疤痕严重程度评分平均改善 75.12%（p<0.001），第 2 组平均改善 69.43%（p<0.001）。比较两组不同类型疤痕的改善程度，治疗后同一组内显示第 2 组的滚动型疤痕改善程度最高（p=0.005）。
结论
苯酚深层脱皮术和 PCI 联合 20%TCA 治疗痤疮后萎缩性疤痕有效。
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