Rebouche C J, Panagides D D, Nelson S E
Department of Pediatrics, University of Iowa College of Medicine, Iowa City 52242.
Am J Clin Nutr. 1990 Nov;52(5):820-4. doi: 10.1093/ajcn/52.5.820.
The role of carnitine in oxidation of dietary medium-chain fatty acids (as medium-chain triglycerides) was studied in term human infants. Infants were fed, alternately, formulas with fat content that was predominantly long-chain triglycerides, or 40% medium-chain triglycerides. Urinary acylcarnitine excretion was significantly higher and the ratio of free to total carnitine was significantly lower when infants were fed the formula with medium-chain triglycerides. Two groups of 10 infants were fed a commercial soy-protein-based formula modified to contain 40% of fat calories as medium-chain triglycerides and with or without added L-carnitine. By 56 d, infants fed the formula without added L-carnitine excreted significantly more medium-chain dicarboxylic acids than did the same infants at 28 d and significantly more than infants consuming the carnitine-supplemented formula at either 28 or 56 d. Results are consistent with a role for carnitine in metabolism of dietary medium-chain triglycerides in infants.
在足月人类婴儿中研究了肉碱在膳食中链脂肪酸（以中链甘油三酯形式）氧化中的作用。婴儿交替喂食脂肪含量主要为长链甘油三酯的配方奶或40%中链甘油三酯的配方奶。当婴儿喂食含中链甘油三酯的配方奶时，尿酰基肉碱排泄显著增加，游离肉碱与总肉碱的比率显著降低。两组各10名婴儿喂食一种经改良的以大豆蛋白为基础的商业配方奶，其中40%的脂肪热量为中链甘油三酯，且添加或不添加L-肉碱。到56天时，喂食未添加L-肉碱配方奶的婴儿排泄的中链二羧酸比28天时显著增多，且比喂食添加肉碱配方奶的婴儿在28天或56天时排泄的中链二羧酸显著增多。结果表明肉碱在婴儿膳食中链甘油三酯代谢中起作用。
