Whyte R K, Whelan D, Hill R, McClorry S
Pediatr Res. 1986 Feb;20(2):122-5. doi: 10.1203/00006450-198602000-00005.
The effects of feeding a commercial formula containing increased amounts of medium-chain fatty acids on the urinary excretions of C6-C10 moncarboxylic, dicarboxylic, and omega-1 hydroxy acids were studied in 13 growing preterm infants of mean birth weight 1.42 kg in a randomized double-blind cross-over clinical trial. Infants were allocated to two sequential feeding regimes of 5 days each, during the last 3 days of which urine was collected and analysed by gas-chromatography mass spectrometry. The two feeding regimes consisted of high energy and protein-containing formulas specially designed for growing low birth weight infants. In one diet the triglyceride component consisted of 46% medium-chain (C8-C10) and 54% long-chain fatty acid residues: in the other it consisted of 4% medium-chain and 96% fatty acid residues. The infants were randomized so that six infants were fed first with the medium-chain predominant formula and seven were fed first with the long-chain predominant formula. There were significant differences in the urinary excretions of octanoate, sebacate, suberate, adipate, 7-hydroxyoctanoate, and 5-hydroxyhexanoate; these substances appearing in much greater quantities in the urine during the period in which medium-chain triglycerides were predominant in the formula. The significance of this organic aciduria, which accounted for 0.7% of the dietary intake of medium-chain triglycerides, remains to be established.
在一项随机双盲交叉临床试验中，对13名平均出生体重为1.42千克的生长中的早产儿进行了研究，以观察喂食含增加量中链脂肪酸的商业配方奶粉对C6 - C10单羧酸、二羧酸和ω-1羟基酸尿排泄的影响。婴儿被分配到两种连续的喂养方案，每种方案为期5天，在最后3天收集尿液并通过气相色谱 - 质谱法进行分析。这两种喂养方案均由专门为低出生体重生长婴儿设计的高能量和高蛋白配方奶粉组成。一种饮食中的甘油三酯成分由46%的中链（C8 - C10）和54%的长链脂肪酸残基组成；另一种饮食中的甘油三酯成分由4%的中链和96%的长链脂肪酸残基组成。婴儿被随机分组，使得6名婴儿首先喂食中链为主的配方奶粉，7名婴儿首先喂食长链为主的配方奶粉。辛酸、癸二酸、辛二酸、己二酸、7-羟基辛酸和5-羟基己酸的尿排泄量存在显著差异；在配方奶粉中中链甘油三酯占主导的时期，这些物质在尿液中的含量要高得多。这种占膳食中链甘油三酯摄入量0.7%的有机酸尿症的意义尚待确定。
