淋巴因子诱导巨噬细胞聚集机制的研究。
Studies on the mechanism of macrophage aggregation induced by lymphokines.
作者信息
Badenoch-Jones P, Rouveix B, Turk J L
出版信息
Immunology. 1979 Jun;37(2):361-6.
Macrophage aggregation (measured by a light-scattering technique) induced by unpurified lymphokine preparations has been investigated. This has been shown to be Ca2+ or Mg2+ dependent and to be inhibited by a number of agents known to affect cellular physiology and biochemistry. The divalent cation ionophore A23187 causes a macrophage aggregation superficially similar to that induced by lymphokines, although differences were found. It is suggested that a biochemical response by the macrophage is required for aggregation induced by lymphokines, and thus measurements of macrophage aggregation allow a study of the early events in the response of macrophages to lymphokines.
对未纯化的淋巴因子制剂诱导的巨噬细胞聚集（通过光散射技术测量）进行了研究。已表明这一过程依赖于Ca2+或Mg2+，并受到许多已知会影响细胞生理学和生物化学的试剂的抑制。二价阳离子载体A23187可引起巨噬细胞聚集，表面上类似于淋巴因子诱导的聚集，尽管也发现了差异。有人提出，淋巴因子诱导的聚集需要巨噬细胞的生化反应，因此巨噬细胞聚集的测量有助于研究巨噬细胞对淋巴因子反应中的早期事件。
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