Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Psychiatry Res. 2012 Apr 30;196(2-3):309-14. doi: 10.1016/j.psychres.2011.09.005. Epub 2012 Mar 5.
Antidepressant usage in prodromal Huntington Disease (HD) remains uncharacterized, despite its relevance in designing experiments, studying outcomes of HD, and evaluating the efficacy of therapeutic interventions. We searched baseline medication logs of 787 prodromal HD and 215 healthy comparison (HC) participants for antidepressant use. Descriptive and mixed-effects logistic regression modeling characterized usage across participants. At baseline, approximately one in five prodromal HD participants took antidepressants. Of those, the vast majority took serotonergic antidepressants (selective serotonin reuptake inhibitor (SSRI) or serotonin/norepinephrine reuptake inhibitor (SNRI)). Significantly more prodromal HD participants used serotonergic antidepressants than their HC counterparts. Because of the prevalence of these medications, further analyses focused on this group alone. Mixed-effects logistic regression modeling revealed significant relationships of both closer proximity to diagnosis and female sex with greater likelihood to be prescribed a serotonergic antidepressant. More prodromal HD participants took antidepressants in general and specifically the subclass of serotonergic antidepressants than their at-risk counterparts, particularly when they were closer to predicted time of conversion to manifest HD. These propensities must be considered in studies of prodromal HD participants.
尽管在设计实验、研究亨廷顿病（HD）的结果和评估治疗干预的疗效方面具有相关性，但在前驱期 HD 中使用抗抑郁药的情况仍不明确。我们在前驱期 HD 787 名和健康对照（HC）215 名参与者的基线用药记录中搜索了抗抑郁药的使用情况。描述性和混合效应逻辑回归模型描述了参与者的使用情况。在基线时，大约五分之一的前驱期 HD 参与者服用了抗抑郁药。其中，绝大多数人服用了血清素能抗抑郁药（选择性 5-羟色胺再摄取抑制剂（SSRI）或 5-羟色胺-去甲肾上腺素再摄取抑制剂（SNRI））。前驱期 HD 参与者使用血清素能抗抑郁药的比例明显高于其 HC 对照组。由于这些药物的普遍性，进一步的分析仅集中在这一组。混合效应逻辑回归模型显示，与诊断的接近程度和女性性别与更有可能被开处方使用血清素能抗抑郁药有显著关系。与高危对照组相比，更多的前驱期 HD 参与者服用了抗抑郁药，特别是在更接近预测的转化为明显 HD 的时间时。在研究前驱期 HD 参与者时，必须考虑这些倾向。
