Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Nicolás Cabrera 1, Madrid 28049, Spain.
Curr Opin Neurobiol. 2012 Jun;22(3):405-11. doi: 10.1016/j.conb.2012.02.008. Epub 2012 Mar 5.
Cell growth and differentiation in developing tissues are, at first impression, quite different endeavors from readjusting synaptic strength during activity-dependent synaptic plasticity in mature neurons. Nevertheless, it is becoming increasingly clear that these two distinct processes share multiple intracellular signaling events. How these common pathways result in cell division (during proliferation), large-scale cellular remodeling (during differentiation) or synapse-specific changes (during synaptic plasticity) is only starting to be elucidated. Here we review the latest findings on two prototypical examples of these shared mechanisms: the Ras-PI3K pathway and the intracellular signaling elicited by neural cell adhesion molecules interacting with growth factor receptors.
在发育组织中，细胞的生长和分化与成熟神经元活动依赖性突触可塑性过程中重新调整突触强度的过程截然不同。然而，越来越明显的是，这两个截然不同的过程共享多个细胞内信号事件。这些共同途径如何导致细胞分裂（增殖过程）、大规模细胞重塑（分化过程）或突触特异性变化（突触可塑性过程），目前才刚刚开始被阐明。在这里，我们回顾了这两个共享机制的典型范例的最新发现：Ras-PI3K 途径和神经细胞黏附分子与生长因子受体相互作用引发的细胞内信号。
